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Evaluation of the indirect impact of the 10-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine in a cluster-randomised trial.

Author: BorysDorota, JokinenJukka, MoreiraMarta, NieminenHeta, PalmuArto A, Rinta-KokkoHanna, RuokokoskiEsa, SchuermanLode

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Clinical Trial, Phase IVPost-marketing surveillance. Monitors long-term safety/efficacy after approval.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study assessed the indirect impact of the 10-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine (PHiD-CV10) against five pneumococcal disease syndromes.
Paper Details　
Original Abstract of the Article :
In the nation-wide double-blind cluster-randomised Finnish Invasive Pneumococcal disease trial (FinIP, ClinicalTrials.gov NCT00861380, NCT00839254), we assessed the indirect impact of the 10-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine (PHiD-CV10) against five pneumococcal ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730423/

データ提供：米国国立医学図書館（NLM）

Pneumococcal Vaccine: A Tale of Indirect Protection

This research delves into the realm of immunology, exploring the indirect effects of a 10-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine (PHiD-CV10). The researchers sought to understand how this vaccine not only protects against pneumococcal disease but also indirectly benefits individuals by preventing other related health problems. They conducted a cluster-randomized trial in Finland, investigating the impact of the vaccine on five different pneumococcal disease syndromes.

The Ripple Effects of Vaccination

The researchers found that the PHiD-CV10 vaccine provided indirect protection against a range of pneumococcal disease syndromes, demonstrating its broader impact on overall health. This highlights the power of vaccination to not only prevent specific diseases but also contribute to a more robust immune system and reduce the burden of illness.

The Value of Vaccination for Public Health

This research reinforces the importance of vaccination for public health, showcasing its potential to protect not only individuals but also communities. It emphasizes the need for continued investment in vaccine research and development to create a healthier and more resilient society.

Dr. Camel's Conclusion

This study demonstrates the far-reaching benefits of vaccination, extending beyond the direct prevention of specific diseases. The researchers' findings highlight the interconnectedness of health and the power of preventive measures to create a healthier and more resilient population. As a health-conscious individual, I applaud the researchers' efforts to shed light on the remarkable benefits of vaccination.

Date :
  1. Date Completed 2022-02-16
  2. Date Revised 2022-02-16
Further Info :

Pubmed ID

34986178

DOI: Digital Object Identifier

PMC8730423

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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