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Preparation of topical bimatoprost with enhanced skin infiltration and <i>in&#160;vivo</i> hair regrowth efficacy in androgenic alopecia.

Author: ChoSeung-Sik, KimBeum Joon, KimKi-Taek, KooKyo-Tan, PandeyPrashant, ParkJin Woo, ShimJung-Hyun, SubediLaxman

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Bimatoprost (BIM) is a drug used to treat glaucoma, but it has also shown potential as a hair growth stimulant. This study investigated a novel topical BIM formulation (BIM-TF#5) designed to enhance skin permeability. The formulation resulted in significantly higher skin flux and dermal drug deposition compared to BIM in ethanol. Furthermore, BIM-TF#5 promoted hair regrowth in an androgenic alopecia mouse model, demonstrating its potential as a treatment for scalp alopecia.
Paper Details　
Original Abstract of the Article :
To prepare a topical formulation of bimatoprost (BIM) with high skin permeability, we designed a solvent mixture system composed of ethanol, diethylene glycol monoethyl ether, cyclomethicone, and butylated hydroxyanisole, serving as a volatile solvent, nonvolatile co-solvent, spreading agent, and an...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774136/

データ提供：米国国立医学図書館（NLM）

A New Oasis for Hair Regrowth: Bimatoprost with Enhanced Skin Infiltration

Hair loss, a common concern for many, can be a challenging problem to address. This study investigates a new topical formulation of bimatoprost (BIM), a medication typically used to treat glaucoma, for promoting hair regrowth in individuals with androgenic alopecia. The researchers designed a novel formulation with enhanced skin penetration and evaluated its efficacy in a mouse model. Their findings suggest that the new BIM formulation effectively promotes hair regrowth, offering a potential new avenue for treating hair loss.

A Promising Approach to Hair Loss Treatment

This study reveals the potential of a new BIM formulation for promoting hair regrowth. The study found that the new formulation significantly increased dermal drug deposition, leading to a significant increase in hair regrowth in the mouse model.

Finding a Solution in the Desert of Hair Loss

This research highlights the importance of exploring innovative approaches to treat hair loss. The study's findings suggest that enhancing skin penetration of BIM could lead to more effective hair regrowth treatments.

Dr. Camel's Conclusion

This study, like a camel discovering a hidden oasis in the vast desert of hair loss treatment, unveils a novel approach for hair regrowth. The new BIM formulation with enhanced skin penetration offers a promising path toward more effective and targeted treatment for androgenic alopecia.

Date :
  1. Date Completed 2022-02-23
  2. Date Revised 2022-02-23
Further Info :

Pubmed ID

35040730

DOI: Digital Object Identifier

PMC8774136

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Article Analysis
・Effects of bimatoprost topical
SNS
PICO Info
in preparation
Languages

English

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