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Influence of Bile Acids in Hydrogel Pharmaceutical Formulations on Dissolution Rate and Permeation of Clindamycin Hydrochloride.
Author: Al-SalamiHani, BogićevićIsidora Anastasija, Goločorbin-KonSvetlana, MikovMomir, PavlovićNebojša, ZaklanDragana, ĐanićMaja
Original Abstract of the Article :
Clindamycin hydrochloride is a widely used antibiotic for topical use, but its main disadvantage is poor skin penetration. Therefore, new approaches in the development of clindamycin topical formulations are of great importance. We aimed to investigate the effects of the type of gelling agent (carbo...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774652/
データ提供:米国国立医学図書館(NLM)
Influence of Bile Acids in Hydrogel Pharmaceutical Formulations on Dissolution Rate and Permeation of Clindamycin Hydrochloride
Imagine a camel crossing a vast desert, carrying precious cargo. This research explores the world of topical drug delivery, focusing on clindamycin hydrochloride, a common antibiotic used for skin infections. The researchers investigated the impact of different gelling agents and bile acids on the release and permeation of clindamycin, similar to studying how different materials affect the camel's ability to transport its cargo. This study provides valuable insights into developing more effective topical drug formulations.
Optimizing Topical Drug Delivery
This study highlights the importance of formulation design in topical drug delivery. It identifies that carmellose sodium hydrogels, a type of gel, demonstrate significantly higher release rates and permeation of clindamycin compared to carbomer gels. This research is like discovering a new type of sand dune that allows for easier and faster travel for the camel. This study emphasizes the importance of choosing the right formulation to enhance drug efficacy and minimize side effects.
Navigating the Landscape of Topical Drug Delivery: Insights for Effective Treatment
This research offers valuable insights into the development of more effective topical antibiotic formulations. By understanding the influence of different components on drug release and permeation, scientists can design formulations that deliver the right amount of medication to the target area. This study, like a map guiding a camel through the desert, provides a roadmap for optimizing topical drug delivery and improving patient outcomes.
Dr. Camel's Conclusion
This research provides valuable insights into the world of topical drug delivery. Like a camel carefully navigating the desert, this study explores the complex interplay of different components to optimize drug release and permeation, ultimately improving patient outcomes.
Date :
- Date Completed n.d.
- Date Revised 2022-01-24
Further Info :
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