Aptamers Entirely Built from Therapeutic Nucleoside Analogues for Targeted Cancer Therapy.

Author: MaYuan, YangJiapei, ZhangChuan, ZhuLijuan, ZhuXinyuan

Paper Details 
Original Abstract of the Article :
Owing to the specific and high binding affinity of aptamers to their targets, aptamer-drug conjugates (ApDCs) have emerged as a promising drug delivery system for targeted cancer therapy. However, in a conventional ApDC, the aptamer segment usually just serves as a targeting moiety, and only a limit...See full text at original site
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引用元:
https://doi.org/10.1021/jacs.1c09574

データ提供:米国国立医学図書館(NLM)

Aptamers for Targeted Cancer Therapy: A New Frontier in Drug Delivery

Cancer therapy is a constantly evolving field, with researchers continually seeking new ways to target and destroy cancer cells while minimizing damage to healthy tissues. This study explores the potential of aptamers, small molecules that bind to specific targets with high affinity, for targeted drug delivery in cancer treatment. The researchers designed a novel approach to create aptamers entirely built from therapeutic nucleoside analogs, which act as both targeting and therapeutic agents.

These 'drugtamers' combine the targeting capabilities of traditional aptamers with the therapeutic potential of clinically approved nucleoside analogs, offering a highly effective and targeted drug delivery system. This is like discovering a new type of oasis in the desert, one that not only provides water but also contains powerful medicinal properties. The researchers demonstrated that these drugtamers effectively induced apoptosis in cancer cells and inhibited tumor growth in preclinical models.

Drugtamers: A Powerful New Weapon in the Fight Against Cancer

This research holds significant promise for the future of cancer treatment. The drugtamers offer a novel and potentially more effective way to deliver targeted therapy, potentially reducing side effects and improving treatment outcomes. This approach could revolutionize the way we treat cancer, offering new hope for patients with this devastating disease. It's like finding a hidden treasure in the desert, a breakthrough that could lead to a new era of cancer treatment.

Harnessing the Power of Precision Medicine: A Personalized Approach to Cancer Care

The study underscores the importance of precision medicine in cancer treatment, where therapies are tailored to the individual patient's needs. This approach allows for a more targeted and effective treatment, minimizing side effects and maximizing therapeutic benefits. It's a reminder that the desert of cancer treatment is full of diverse options, and understanding the specific needs of each patient is crucial for finding the most effective path to recovery.

Dr.Camel's Conclusion

This study provides a glimpse into the future of targeted cancer therapy, highlighting the exciting potential of 'drugtamers' as a powerful new weapon in the fight against this devastating disease. It's a reminder that the desert of cancer research is vast and full of potential, and with continued innovation and discovery, we can find more effective ways to treat and cure this disease.

Date :
  1. Date Completed 2022-03-07
  2. Date Revised 2022-03-07
Further Info :

Pubmed ID

35073490

DOI: Digital Object Identifier

10.1021/jacs.1c09574

Related Literature

SNS
PICO Info
in preparation
Languages

English

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