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Implication of body mass index (BMI) on the biological and clinical effects of endocrine therapy plus abemaciclib as neoadjuvant therapy for early breast cancer patients.

Author: BruzzoneMarco, CeppiMarcello, FranzoiMaria Alice, LambertiniMatteo, de AzambujaEvandro

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the impact of body mass index (BMI) on the effectiveness of abemaciclib plus endocrine therapy in patients with advanced breast cancer. Patients with a BMI of 25 or higher showed an inferior overall response rate compared to those with a lower BMI.
Paper Details　
Original Abstract of the Article :
Inferior overall response rate with abemaciclib plus endocrine therapy was observed in patients with hormone receptor-positive/HER2-negative advanced breast cancer (BC) and BMI ≥ 25. We assessed the impact of baseline BMI on KI67% changes, achievement of complete cell cycle arrest (CCCA), clinical, ...See full text at original site
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引用元：
https://doi.org/10.1007/s10549-022-06525-3

データ提供：米国国立医学図書館（NLM）

Body Mass Index (BMI) and Breast Cancer Treatment: A New Twist in the Desert of Cancer Research

The vast desert of cancer research is constantly evolving, and this study examines the complex interplay between BMI and the effectiveness of certain breast cancer treatments. Specifically, the researchers explored the impact of BMI on the effectiveness of endocrine therapy plus abemaciclib, a drug that inhibits the growth of breast cancer cells, as neoadjuvant therapy for early breast cancer patients.

BMI's Impact on Breast Cancer Treatment: A Case for Personalized Medicine

The study found that patients with a BMI of 25 or higher had an inferior overall response rate to the combined treatment compared to those with a lower BMI. This suggests that BMI may be an important factor to consider when developing personalized treatment plans for breast cancer patients. It's like discovering a hidden oasis in the desert, revealing a previously unknown aspect of breast cancer treatment.

A New Perspective on Breast Cancer Treatment: Tailoring Therapy to the Individual

This research highlights the importance of considering factors beyond just the type of cancer when deciding on treatment strategies. BMI, a seemingly simple measure, can have a significant impact on the effectiveness of certain treatments. This emphasizes the need for a more personalized approach to cancer treatment, taking into account individual characteristics and tailoring therapy accordingly. It's like finding a new compass in the desert, guiding us toward more effective and individualized treatment strategies for breast cancer patients.

Dr.Camel's Conclusion

This study reveals a fascinating connection between BMI and the effectiveness of certain breast cancer treatments. It emphasizes the importance of considering individual factors like BMI when developing personalized treatment plans, reminding us that the desert of cancer research is full of hidden oases waiting to be discovered.
Date :
  1. Date Completed 2022-03-18
  2. Date Revised 2022-05-31
Further Info :

Pubmed ID

35076812

DOI: Digital Object Identifier

10.1007/s10549-022-06525-3

Related Literature

Article Analysis
・Effects of abemaciclib
SNS
PICO Info
in preparation
Languages

English

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