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Effects of CYP2C19, CYP2C9 and CYP3A4 gene polymorphisms on plasma voriconazole levels in Chinese pediatric patients.

Author: FanXinghua, WenZhipeng, YangJihong, YangYi, ZhangHong, ZhengXiaoli

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study aimed to investigate the effects of CYP2C19, CYP2C9, and CYP3A4 gene polymorphisms on plasma voriconazole concentrations in Chinese pediatric patients.
Paper Details　
Original Abstract of the Article :
Voriconazole is the most commonly used antifungal agent in clinical application. Previous studies suggested that voriconazole was extensively metabolized by CYP450 enzyme system, including CYP2C19, CYP2C9 and CYP3A4, which contributed to the individual variability of the pharmacokinetic process of v...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/35081606

データ提供：米国国立医学図書館（NLM）

Investigating the Impact of CYP450 Polymorphisms on Voriconazole Levels in Chinese Pediatric Patients

Voriconazole, a widely used antifungal agent, is extensively metabolized by the CYP450 enzyme system. This study delves into the impact of CYP2C19, CYP2C9, and CYP3A4 gene polymorphisms on plasma voriconazole concentrations in Chinese pediatric patients. By understanding the variability in drug metabolism, clinicians can personalize drug therapy, optimizing therapeutic outcomes and minimizing potential adverse effects.

Tailoring Treatment for Individual Needs

The study highlights the importance of considering genetic variations in drug metabolism. By identifying individuals with specific CYP450 polymorphisms, clinicians can tailor voriconazole dosing, ensuring optimal drug efficacy and minimizing the risk of adverse effects. This approach is crucial for personalized medicine, allowing for more effective and safer treatment outcomes.

Navigating the Complexities of Drug Metabolism

This study adds to our understanding of the complex interplay between genetic variations and drug metabolism. It reminds us that individuals respond differently to medications, and understanding these differences is crucial for effective and safe treatment. This research contributes to the growing field of pharmacogenomics, paving the way for personalized drug therapy and improved patient care.

Dr.Camel's Conclusion

This study underscores the critical role of genetic variations in drug metabolism. By understanding the impact of CYP450 polymorphisms on voriconazole levels, clinicians can personalize treatment strategies, optimizing efficacy and minimizing adverse effects. This research contributes to the growing field of pharmacogenomics, paving the way for more effective and safer drug therapies.

Date :
  1. Date Completed 2022-05-09
  2. Date Revised 2023-09-11
Further Info :

Pubmed ID

35081606

DOI: Digital Object Identifier

01213011-202206000-00004

Related Literature

Article Analysis
・Effects of voriconazole
SNS
PICO Info
in preparation
Languages

English

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