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Structure-based discovery of nonhallucinogenic psychedelic analogs.
Author: CaoDongmei, ChenZhangcheng, ChengJianjun, FanLuyu, HeLicong, LiJinsong, LiuXinyu, LuoZhipu, QiJianzhong, TangLingjie, WangHuan, WangSheng, YuJing
Original Abstract of the Article :
Drugs that target the human serotonin 2A receptor (5-HT<sub>2A</sub>R) are used to treat neuropsychiatric diseases; however, many have hallucinogenic effects, hampering their use. Here, we present structures of 5-HT<sub>2A</sub>R complexed with the psychedelic drugs psilocin (the active metabolite o...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1126/science.abl8615
データ提供:米国国立医学図書館(NLM)
Psychedelic Drugs: A Desert Mirage of Hope for Neuropsychiatric Diseases
The field of [neuropsychiatric diseases] is a vast and often perplexing landscape, with many conditions still lacking effective treatments. This study, like a desert explorer seeking new routes, delves into the realm of [psychedelic drugs], investigating their potential as therapeutic agents. The authors, armed with [structural biology and computational drug design techniques], investigated the interactions between [psychedelic drugs] and the [human serotonin 2A receptor (5-HT2AR)], uncovering key insights into the mechanisms underlying their effects. Their findings, like a shimmering oasis, reveal that [certain modifications to psychedelic drugs can eliminate their hallucinogenic properties while retaining therapeutic benefits]. This discovery opens a new path for developing safe and effective treatments for neuropsychiatric diseases, offering a beacon of hope for those seeking relief from these challenging conditions.
Nonhallucinogenic Psychedelics: A Mirage of Potential
The study's findings, like a caravan discovering a hidden spring, suggest that [it may be possible to design nonhallucinogenic psychedelic analogs that retain therapeutic properties]. This is a groundbreaking discovery, as it potentially unlocks the door to a new generation of drugs for treating neuropsychiatric diseases without the unwanted side effects of traditional psychedelics. This is like finding a hidden pathway through the desert, offering a safer and more effective route to treatment.
Navigating the Desert of Neuropsychiatric Disease: A New Path to Treatment
For those living with [neuropsychiatric diseases], this study offers a glimmer of hope. It suggests that [nonhallucinogenic psychedelic analogs] could potentially provide effective treatment options, offering a new path to recovery and well-being. It's like discovering a hidden well in the desert, providing a source of hope and possibility for those seeking relief from these challenging conditions.
Dr.Camel's Conclusion
This study, like a camel navigating the vast desert of [neuropsychiatric research], offers a groundbreaking discovery, paving the way for the development of [nonhallucinogenic psychedelic analogs] as potential treatments for neuropsychiatric diseases. The study's findings, like a shimmering mirage, hold the promise of a new era of therapeutic treatments, offering hope for those seeking relief from these challenging conditions.
Date :
- Date Completed 2022-02-14
- Date Revised 2022-04-26
Further Info :
Related Literature
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