Structure-based discovery of nonhallucinogenic psychedelic analogs.

Author: CaoDongmei, ChenZhangcheng, ChengJianjun, FanLuyu, HeLicong, LiJinsong, LiuXinyu, LuoZhipu, QiJianzhong, TangLingjie, WangHuan, WangSheng, YuJing

Paper Details 
Original Abstract of the Article :
Drugs that target the human serotonin 2A receptor (5-HT<sub>2A</sub>R) are used to treat neuropsychiatric diseases; however, many have hallucinogenic effects, hampering their use. Here, we present structures of 5-HT<sub>2A</sub>R complexed with the psychedelic drugs psilocin (the active metabolite o...See full text at original site
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引用元:
https://doi.org/10.1126/science.abl8615

データ提供:米国国立医学図書館(NLM)

Psychedelic Drugs: A Desert Mirage of Hope for Neuropsychiatric Diseases

The field of [neuropsychiatric diseases] is a vast and often perplexing landscape, with many conditions still lacking effective treatments. This study, like a desert explorer seeking new routes, delves into the realm of [psychedelic drugs], investigating their potential as therapeutic agents. The authors, armed with [structural biology and computational drug design techniques], investigated the interactions between [psychedelic drugs] and the [human serotonin 2A receptor (5-HT2AR)], uncovering key insights into the mechanisms underlying their effects. Their findings, like a shimmering oasis, reveal that [certain modifications to psychedelic drugs can eliminate their hallucinogenic properties while retaining therapeutic benefits]. This discovery opens a new path for developing safe and effective treatments for neuropsychiatric diseases, offering a beacon of hope for those seeking relief from these challenging conditions.

Nonhallucinogenic Psychedelics: A Mirage of Potential

The study's findings, like a caravan discovering a hidden spring, suggest that [it may be possible to design nonhallucinogenic psychedelic analogs that retain therapeutic properties]. This is a groundbreaking discovery, as it potentially unlocks the door to a new generation of drugs for treating neuropsychiatric diseases without the unwanted side effects of traditional psychedelics. This is like finding a hidden pathway through the desert, offering a safer and more effective route to treatment.

Navigating the Desert of Neuropsychiatric Disease: A New Path to Treatment

For those living with [neuropsychiatric diseases], this study offers a glimmer of hope. It suggests that [nonhallucinogenic psychedelic analogs] could potentially provide effective treatment options, offering a new path to recovery and well-being. It's like discovering a hidden well in the desert, providing a source of hope and possibility for those seeking relief from these challenging conditions.

Dr.Camel's Conclusion

This study, like a camel navigating the vast desert of [neuropsychiatric research], offers a groundbreaking discovery, paving the way for the development of [nonhallucinogenic psychedelic analogs] as potential treatments for neuropsychiatric diseases. The study's findings, like a shimmering mirage, hold the promise of a new era of therapeutic treatments, offering hope for those seeking relief from these challenging conditions.

Date :
  1. Date Completed 2022-02-14
  2. Date Revised 2022-04-26
Further Info :

Pubmed ID

35084960

DOI: Digital Object Identifier

10.1126/science.abl8615

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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