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Effects of formulation and food on the absorption of hydrochlorothiazide and triamterene or amiloride from combination diuretic products.

Author: BenetL Z, BlumeC D, GeeW L, LinE T, MordentiJ, UptonR A, WilliamsR L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Three combination formulations of hydrochlorothiazide with either triamterene or amiloride were studied for their absorption under different food conditions. The most widely prescribed formulation, containing 25 mg of hydrochlorothiazide and 50 mg of triamterene, demonstrated impaired absorption when fasting, which was partially corrected by a high-fat breakfast. The new formulation containing 50 mg of hydrochlorothiazide and 75 mg of triamterene showed acceptable absorption in the fasting state and was not affected by a high-fat breakfast. The combination of 50 mg hydrochlorothiazide and 5 mg amiloride demonstrated acceptable absorption in the fasting state, with a slight reduction in amiloride absorption when administered with a high-fat meal.
Paper Details　
Original Abstract of the Article :
The absorption of three combination formulations of hydrochlorothiazide and either triamterene or amiloride was studied over a 5-year period in seven separate investigations under varying conditions of food and fasting. The most widely prescribed combination, containing 25 mg of hydrochlorothiazide ...See full text at original site
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引用元：
https://doi.org/10.1023/a:1016409606936

データ提供：米国国立医学図書館（NLM）

Hydrochlorothiazide and Triamterene/Amiloride Combinations: A Study on Absorption

Combination diuretic medications, which combine multiple drugs to enhance their effects, are often prescribed to manage blood pressure and fluid retention. This study, conducted in 1993, investigated the absorption of different combination formulations containing hydrochlorothiazide and either triamterene or amiloride, exploring the influence of food intake on drug absorption. The researchers conducted a series of investigations under varying conditions of food and fasting, analyzing the absorption of the medications. Their results showed that the absorption of certain formulations was influenced by food, highlighting the importance of considering these factors when prescribing combination diuretic medications.

Food's Influence on Diuretic Absorption: A Complex Interaction

This study underscores the influence of food on the absorption of combination diuretic medications. The findings highlight the importance of considering meal timing and food composition when prescribing these medications, as they can significantly impact drug absorption and effectiveness. The research emphasizes the need for a personalized approach to diuretic therapy, taking into account individual factors that may influence drug absorption.

Optimizing Diuretic Therapy: A Holistic Approach

This research sheds light on the complex interaction between food and the absorption of combination diuretic medications. The findings emphasize the need for a holistic approach to diuretic therapy, considering individual factors such as food intake and drug formulation. The study highlights the importance of patient education and close monitoring to ensure optimal drug absorption and therapeutic outcomes.

Dr. Camel's Conclusion

Just as a camel adapts its feeding habits to the availability of water and food in the desert, understanding the interaction between food and diuretic absorption is essential for optimizing treatment outcomes. This study emphasizes the need for a personalized approach to diuretic therapy, considering individual factors and ensuring optimal drug absorption for effective treatment.

Date :
  1. Date Completed 1989-06-12
  2. Date Revised 2019-08-18
Further Info :

Pubmed ID

3508542

DOI: Digital Object Identifier

10.1023/a:1016409606936

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Languages

English

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