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Clinically actionable genotypes for anticancer prescribing among >1500 patients with pharmacogenomic testing.

Author: DanaheyKeith, GeorgeDavid, HouseLarry K, KarrisonTheodore G, O'DonnellPeter H, RatainMark J, ReizineNatalie M, TruongTien M, YeoKiang-Teck J, van WijkXander M R

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study argues that comprehensive germline pharmacogenomic profiling could be highly relevant for cancer care due to increasing evidence supporting the role of such factors in predicting toxicity for anticancer therapies.
Paper Details　
Original Abstract of the Article :
In recent years, there has been increasing evidence supporting the role of germline pharmacogenomic factors predicting toxicity for anticancer therapies. Although somatic genomic data are used frequently in oncology care planning, germline pharmacogenomic testing is not. This study hypothesizes that...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/35090043

データ提供：米国国立医学図書館（NLM）

Pharmacogenomics in Cancer Care: A Personalized Approach to Anticancer Prescribing

The field of [pharmacogenomics] is rapidly changing the landscape of medicine by providing personalized insights into drug responses. This study investigates the potential of comprehensive germline pharmacogenomic profiling in guiding anticancer therapy decisions. While somatic genomic data is routinely used in oncology, the role of germline pharmacogenomics in cancer care remains relatively unexplored.

The study analyzed data from over 1500 patients and identified clinically actionable genotypes that could predict toxicity for anticancer therapies. These findings highlight the potential of germline pharmacogenomic profiling to personalize cancer care, enabling clinicians to tailor treatment regimens to individual patient needs and minimize potential adverse effects.

Unlocking Personalized Cancer Care: The Power of Pharmacogenomics

The study demonstrates the significant potential of germline pharmacogenomics in enhancing the safety and effectiveness of anticancer therapy. By understanding an individual's genetic predisposition to drug responses, clinicians can optimize treatment plans, potentially improving outcomes and reducing side effects.

A New Era of Personalized Medicine: Tailored Therapies for Optimal Outcomes

The research suggests that incorporating germline pharmacogenomic testing into routine cancer care could revolutionize how we approach anticancer therapy. This personalized approach, based on an individual's unique genetic makeup, could lead to more targeted and effective treatments, ultimately improving patient outcomes.

Dr.Camel's Conclusion

Just as a desert traveler navigates with the help of a compass, pharmacogenomics can guide us towards a more personalized and effective approach to cancer care. By understanding the genetic blueprint of each patient, we can navigate the complex landscape of anticancer therapies with greater precision, ultimately leading to better outcomes and a brighter future for those battling this disease.

Date :
  1. Date Completed 2022-04-06
  2. Date Revised 2023-04-16
Further Info :

Pubmed ID

35090043

DOI: Digital Object Identifier

NIHMS1770188

SNS
PICO Info
in preparation
Languages

English

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