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Effect of Naloxegol on Opioid-Induced Esophageal Motility Disorder.

Author: CiezkiKristin, JacobsonMegan, SharmaTarun, SighMaharaj, UlteigCrista

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Overview

This case series reports that 3 patients with coexisting esophageal dysmotility and constipation on chronic opioids experienced improvement in both symptoms after starting naloxegol. This suggests that naloxegol may be beneficial for opioid-induced esophageal dysmotility, and further studies are needed to confirm this finding.
Paper Details　
Original Abstract of the Article :
Opioid effects on lower gastrointestinal motility are well documented, and increasing attention is being paid to their effect on esophageal motility. Naloxegol is a µ-opioid receptor antagonist that is used for opioid-induced constipation, but its impact on esophageal motility has not been well docu...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791044/

データ提供：米国国立医学図書館（NLM）

Naloxegol: A Potential Solution for Opioid-Induced Esophageal Motility Disorder

Opioids are commonly used for pain relief, but they can have significant side effects on gastrointestinal motility. This case series explores the potential of naloxegol, a medication for opioid-induced constipation, to also improve esophageal motility in patients experiencing dysmotility related to opioid use.

Naloxegol: A Promising Solution for Opioid-Related Motility Problems

This case series suggests that naloxegol may offer a potential solution for patients experiencing opioid-induced esophageal dysmotility. The authors observed improvements in both constipation and esophageal symptoms after starting naloxegol. It's like finding a hidden oasis in the desert of opioid-related gastrointestinal problems, offering a potential solution for a complex and often debilitating condition.

Understanding Opioid Side Effects: A Journey of Gastrointestinal Health

This research highlights the importance of understanding the complex interplay between opioids and gastrointestinal motility. It encourages further investigation into the potential benefits of naloxegol in addressing opioid-induced esophageal dysmotility, potentially improving the quality of life for patients experiencing these challenging side effects. It's like exploring a new frontier in gastrointestinal health, seeking to understand the mechanisms by which opioids affect motility and to discover effective interventions for these problems.

Dr.Camel's Conclusion

This case series offers a promising glimpse into the potential of naloxegol for treating opioid-induced esophageal dysmotility. It underscores the need for further research to investigate this promising treatment option, potentially leading to improved outcomes for patients experiencing these debilitating side effects. It's like finding a new path through the desert of opioid-related gastrointestinal problems, offering hope for a smoother and more comfortable journey.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-02-19
Further Info :

Pubmed ID

35097149

DOI: Digital Object Identifier

PMC8791044

Related Literature

Article Analysis
・Effects of naloxegol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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