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Weekly treatment with SAMiRNA targeting the androgen receptor ameliorates androgenetic alopecia.

Author: ChoiSoon Ja, ChoiWoorim, GohEun-Ah, KimJangseon, KimSin Hae, KwonOh Seung, KyongKeeyeol, LeeMi Sun, LeeSang-Kyu, LimSeung Sik, MoonTae Kee, NamGaewon, ParkHan-Oh, YunSung-Il

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study demonstrated that self-assembled micelle inhibitory RNA (SAMiRNA) nanoparticles selectively suppressed androgen receptor (AR) expression in vitro, with clinical studies confirming its efficacy in androgenetic alopecia (AGA). SAMiRNA-AR68 was found to be a potent AR silencer that could be efficiently delivered to hair follicles, leading to decreased AR mRNA and protein levels. Clinical studies showed that SAMiRNA targeting AR mRNA could be a potential novel topical treatment for AGA.
Paper Details　
Original Abstract of the Article :
Androgenetic alopecia (AGA) is the most common type of hair loss in men and women. Dihydrotestosterone (DHT) and androgen receptor (AR) levels are increased in patients with AGA, and DHT-AR signaling correlates strongly with AGA pathogenesis. In this study, treatment with self-assembled micelle inhi...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803970/

データ提供：米国国立医学図書館（NLM）

SAMiRNA: A Promising New Treatment for Androgenetic Alopecia

Androgenetic alopecia (AGA), commonly known as male pattern baldness, affects millions of people worldwide. This study explores the potential of a novel therapeutic approach using self-assembled micelle inhibitory RNA (SAMiRNA) nanoparticles to target and silence the androgen receptor (AR), a key player in AGA pathogenesis. The researchers designed a SAMiRNA that specifically suppresses AR expression both in vitro and in vivo. Clinical trials demonstrated the efficacy of this targeted therapy in promoting hair regrowth, providing a potential alternative to existing treatments for AGA.

SAMiRNA: A Targeted Strike Against Hair Loss

The study's findings suggest that SAMiRNA, like a well-aimed arrow in the desert, effectively targets and silences the androgen receptor, a crucial factor in AGA. The clinical trials showed significant increases in hair counts, suggesting that SAMiRNA holds promise as a safe and effective treatment for AGA. The results are encouraging and pave the way for further research and development of this novel therapeutic approach.

Taking Control of Hair Loss

AGA can be a distressing condition, but this research offers a glimmer of hope. The development of SAMiRNA provides a potential new weapon in the fight against hair loss, offering a targeted and effective treatment option. As Dr. Camel, I believe that science, like a gentle desert breeze, can bring us closer to solutions for even the most challenging problems.

Dr. Camel's Conclusion

This study, like a desert oasis providing a refreshing reprieve from the heat, offers hope for those affected by AGA. The development of SAMiRNA represents a significant advancement in the treatment of hair loss, providing a potential solution that is both effective and safe. As Dr. Camel, I encourage you to stay informed about this exciting development and explore the options available for managing your hair loss.

Date :
  1. Date Completed 2022-03-03
  2. Date Revised 2022-10-23
Further Info :

Pubmed ID

35102171

DOI: Digital Object Identifier

PMC8803970

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English

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