Safety and Efficacy of Eluxadoline in Patients with Irritable Bowel Syndrome-Diarrhea With or Without Bile Acid Diarrhea: Open-Label Study.

Author: BoinpallyRamesh, Breen-LylesMargaret, BusciglioIrene, CamilleriMichael, CarrothersTimothy J, MaselliDaniel, MuslinAnna, NordSara Linker, VijayvargiyaPriya

Paper Details 
Original Abstract of the Article :
BACKGROUND: Eluxadoline, a peripherally acting, mixed µ- and κ-opioid receptor (OR) agonist and δ-OR antagonist, is approved for treatment of adults with irritable bowel syndrome-diarrhea (IBS-D). About a third of IBS-D patients has bile acid diarrhea (BAD); opioids may stimulate TGR5 (bile acid) re...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1007/s10620-022-07379-x

データ提供:米国国立医学図書館(NLM)

Eluxadoline: A New Oasis in the Desert of Irritable Bowel Syndrome

The [gastrointestinal condition] known as [irritable bowel syndrome-diarrhea (IBS-D)] can be a debilitating condition, disrupting daily life. This study explores the efficacy and safety of [eluxadoline] in treating IBS-D, both with and without [bile acid diarrhea (BAD)]. Imagine a traveler in a vast desert, seeking relief from the scorching heat and dehydration. Eluxadoline, in this analogy, could be seen as a refreshing oasis, providing relief and restoring balance to the digestive system. The researchers conducted a [phase 4, parallel-group, open-label study] to assess the effectiveness of eluxadoline in managing IBS-D symptoms.

Eluxadoline: A Beacon of Hope for IBS-D Patients

The study found that [eluxadoline] was effective in improving [stool consistency] and reducing [bowel movement frequency] in patients with IBS-D, both with and without BAD. These findings suggest that eluxadoline may be a valuable treatment option for a broader range of IBS-D patients. Moreover, the study revealed that [eluxadoline was well tolerated] and did not lead to any serious adverse events. This is encouraging news, as it suggests that eluxadoline can offer relief from IBS-D symptoms without significant side effects.

Finding Relief in the Desert of IBS-D: Navigating the Path to Wellness

This study provides a glimmer of hope for those suffering from IBS-D. Eluxadoline offers a potential solution for managing this challenging condition, offering relief from symptoms and improving quality of life. It is important to remember that treatment options may vary based on individual needs and circumstances. Consulting with a healthcare professional is crucial to determine the best course of treatment for your specific IBS-D symptoms.

Dr. Camel's Conclusion

This research provides a valuable addition to our understanding of IBS-D treatment. Eluxadoline holds promise as a safe and effective option for managing symptoms, offering hope for those navigating the often-unpredictable terrain of this condition. It is a reminder that continued research and innovation are essential in finding new solutions for those who struggle with chronic gastrointestinal disorders.

Date :
  1. Date Completed 2022-07-19
  2. Date Revised 2022-08-19
Further Info :

Pubmed ID

35122592

DOI: Digital Object Identifier

10.1007/s10620-022-07379-x

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.