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Safety and Efficacy of Eluxadoline in Patients with Irritable Bowel Syndrome-Diarrhea With or Without Bile Acid Diarrhea: Open-Label Study.
Author: BoinpallyRamesh, Breen-LylesMargaret, BusciglioIrene, CamilleriMichael, CarrothersTimothy J, MaselliDaniel, MuslinAnna, NordSara Linker, VijayvargiyaPriya
Original Abstract of the Article :
BACKGROUND: Eluxadoline, a peripherally acting, mixed µ- and κ-opioid receptor (OR) agonist and δ-OR antagonist, is approved for treatment of adults with irritable bowel syndrome-diarrhea (IBS-D). About a third of IBS-D patients has bile acid diarrhea (BAD); opioids may stimulate TGR5 (bile acid) re...See full text at original site
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引用元:
https://doi.org/10.1007/s10620-022-07379-x
データ提供:米国国立医学図書館(NLM)
Eluxadoline: A New Oasis in the Desert of Irritable Bowel Syndrome
The [gastrointestinal condition] known as [irritable bowel syndrome-diarrhea (IBS-D)] can be a debilitating condition, disrupting daily life. This study explores the efficacy and safety of [eluxadoline] in treating IBS-D, both with and without [bile acid diarrhea (BAD)]. Imagine a traveler in a vast desert, seeking relief from the scorching heat and dehydration. Eluxadoline, in this analogy, could be seen as a refreshing oasis, providing relief and restoring balance to the digestive system. The researchers conducted a [phase 4, parallel-group, open-label study] to assess the effectiveness of eluxadoline in managing IBS-D symptoms.
Eluxadoline: A Beacon of Hope for IBS-D Patients
The study found that [eluxadoline] was effective in improving [stool consistency] and reducing [bowel movement frequency] in patients with IBS-D, both with and without BAD. These findings suggest that eluxadoline may be a valuable treatment option for a broader range of IBS-D patients. Moreover, the study revealed that [eluxadoline was well tolerated] and did not lead to any serious adverse events. This is encouraging news, as it suggests that eluxadoline can offer relief from IBS-D symptoms without significant side effects.
Finding Relief in the Desert of IBS-D: Navigating the Path to Wellness
This study provides a glimmer of hope for those suffering from IBS-D. Eluxadoline offers a potential solution for managing this challenging condition, offering relief from symptoms and improving quality of life. It is important to remember that treatment options may vary based on individual needs and circumstances. Consulting with a healthcare professional is crucial to determine the best course of treatment for your specific IBS-D symptoms.
Dr. Camel's Conclusion
This research provides a valuable addition to our understanding of IBS-D treatment. Eluxadoline holds promise as a safe and effective option for managing symptoms, offering hope for those navigating the often-unpredictable terrain of this condition. It is a reminder that continued research and innovation are essential in finding new solutions for those who struggle with chronic gastrointestinal disorders.
Date :
- Date Completed 2022-07-19
- Date Revised 2022-08-19
Further Info :
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