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Leflunomide-induced liver injury: Differences in characteristics and outcomes in Indian and US registries.
Author: BarnhartHuiman, BonkovskyHerbert L, ChalasaniNaga, DevarbhaviHarshad, GhabrilMarwan, GuJiezhun, PatilMallikarjun, RajSujata
Original Abstract of the Article :
Leflunomide, a disease-modifying anti-rheumatic drug, has been associated with elevations of serum aminotransferases. Herein, we describe the clinical, laboratory features and outcomes of 17 patients with leflunomide/teriflunomide hepatotoxicity from two large drug-induced liver injury (DILI) regist...See full text at original site
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://pubmed.ncbi.nlm.nih.gov/35129282
データ提供:米国国立医学図書館(NLM)
Leflunomide-Induced Liver Injury: A Comparative Study
This research investigates the potential risks associated with leflunomide, a disease-modifying anti-rheumatic drug, focusing on the specific issue of liver injury. The study compares the clinical and laboratory characteristics of leflunomide-induced liver injury (DILI) in patients from India and the United States, highlighting potential differences in the presentation and outcomes of this adverse effect. The research underscores the importance of considering geographic variations in DILI, prompting clinicians to be vigilant and adapt their monitoring and management strategies accordingly. The study also highlights the need for further research to understand the factors contributing to these observed differences.Navigating Global Health: Understanding Geographic Variations in Drug Safety
This research draws attention to the importance of considering geographic variations in drug safety. The study reveals potential differences in the presentation and outcomes of leflunomide-induced liver injury (DILI) between patients from India and the United States. It's like discovering two distinct oases in the vast desert of DILI, highlighting the need for a nuanced understanding of drug safety across different populations. These findings emphasize the importance of global collaboration and research to enhance drug safety and optimize patient care.Leflunomide: Balancing Benefits and Risks
Leflunomide offers potential benefits in managing certain rheumatic conditions, but it can also pose risks, including liver injury. This research underscores the need for vigilance and careful monitoring in patients taking leflunomide, particularly in light of the potential for geographic variations in DILI. It's like navigating a desert landscape, recognizing that different paths may require different precautions. Remember, open communication with your healthcare provider is crucial for managing medications effectively and minimizing potential risks.Dr. Camel's Conclusion
This research examines the potential risks associated with leflunomide, a disease-modifying anti-rheumatic drug, focusing on liver injury. The study highlights potential geographic variations in the presentation and outcomes of leflunomide-induced liver injury. These findings emphasize the importance of considering global health perspectives and adapting monitoring and management strategies accordingly. It's like discovering diverse paths in the vast desert of drug safety, highlighting the need for a nuanced and vigilant approach.Date :
- Date Completed 2022-06-10
- Date Revised 2023-10-07
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