Leflunomide-induced liver injury: Differences in characteristics and outcomes in Indian and US registries.

Author: BarnhartHuiman, BonkovskyHerbert L, ChalasaniNaga, DevarbhaviHarshad, GhabrilMarwan, GuJiezhun, PatilMallikarjun, RajSujata

Paper Details 
Original Abstract of the Article :
Leflunomide, a disease-modifying anti-rheumatic drug, has been associated with elevations of serum aminotransferases. Herein, we describe the clinical, laboratory features and outcomes of 17 patients with leflunomide/teriflunomide hepatotoxicity from two large drug-induced liver injury (DILI) regist...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://pubmed.ncbi.nlm.nih.gov/35129282

データ提供:米国国立医学図書館(NLM)

Leflunomide-Induced Liver Injury: A Comparative Study

This research investigates the potential risks associated with leflunomide, a disease-modifying anti-rheumatic drug, focusing on the specific issue of liver injury. The study compares the clinical and laboratory characteristics of leflunomide-induced liver injury (DILI) in patients from India and the United States, highlighting potential differences in the presentation and outcomes of this adverse effect. The research underscores the importance of considering geographic variations in DILI, prompting clinicians to be vigilant and adapt their monitoring and management strategies accordingly. The study also highlights the need for further research to understand the factors contributing to these observed differences.

Navigating Global Health: Understanding Geographic Variations in Drug Safety

This research draws attention to the importance of considering geographic variations in drug safety. The study reveals potential differences in the presentation and outcomes of leflunomide-induced liver injury (DILI) between patients from India and the United States. It's like discovering two distinct oases in the vast desert of DILI, highlighting the need for a nuanced understanding of drug safety across different populations. These findings emphasize the importance of global collaboration and research to enhance drug safety and optimize patient care.

Leflunomide: Balancing Benefits and Risks

Leflunomide offers potential benefits in managing certain rheumatic conditions, but it can also pose risks, including liver injury. This research underscores the need for vigilance and careful monitoring in patients taking leflunomide, particularly in light of the potential for geographic variations in DILI. It's like navigating a desert landscape, recognizing that different paths may require different precautions. Remember, open communication with your healthcare provider is crucial for managing medications effectively and minimizing potential risks.

Dr. Camel's Conclusion

This research examines the potential risks associated with leflunomide, a disease-modifying anti-rheumatic drug, focusing on liver injury. The study highlights potential geographic variations in the presentation and outcomes of leflunomide-induced liver injury. These findings emphasize the importance of considering global health perspectives and adapting monitoring and management strategies accordingly. It's like discovering diverse paths in the vast desert of drug safety, highlighting the need for a nuanced and vigilant approach.
Date :
  1. Date Completed 2022-06-10
  2. Date Revised 2023-10-07
Further Info :

Pubmed ID

35129282

DOI: Digital Object Identifier

NIHMS1778185

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.