Targeted treprostinil delivery inhibits pulmonary arterial remodeling.

Author: LiBin, LiuAijun, ShiYongying, SuJunwu, YangMing

Paper Details 
Original Abstract of the Article :
Pulmonary arterial hypertension (PAH) is a fatal disease caused by the progressive remodeling of pulmonary arteries (PAs). Treprostinil (TPS) is a tricyclic benzidine prostacyclin clinically used for PAH treatment. However, due to low bioavailability, short half-times, and severe systemic side effec...See full text at original site
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引用元:
https://doi.org/10.1016/j.ejphar.2021.174700

データ提供:米国国立医学図書館(NLM)

Targeted Therapy for Pulmonary Arterial Hypertension

[Pulmonary arterial hypertension (PAH)] is a [fatal disease] characterized by [progressive remodeling] of [pulmonary arteries (PAs)]. This study explores the potential of [targeted treprostinil delivery] as a therapeutic approach to [inhibiting pulmonary arterial remodeling] and improving [clinical outcomes] in patients with [PAH]. Researchers investigated the efficacy of [treprostinil (TPS)] delivered directly to the [pulmonary arteries], aiming to overcome the limitations associated with [systemic administration].

The Promise of Targeted Treprostinil Delivery

The study highlights the potential benefits of [targeted treprostinil delivery], suggesting that it could offer a more effective and safer treatment option for [PAH]. By delivering [TPS] directly to the [pulmonary arteries], researchers aim to increase its [bioavailability] and [efficacy] while minimizing [systemic side effects]. It's like finding a hidden spring in the desert that provides a direct source of water to nourish the surrounding ecosystem, minimizing the need for extensive irrigation networks and reducing the risk of water loss.

A New Frontier in PAH Treatment

This research represents a promising step forward in the development of [targeted therapies] for [PAH]. It's like discovering a hidden oasis in the desert, offering hope for new and effective treatment strategies. This approach could potentially improve the [quality of life] and [prognosis] for patients with [PAH], offering a glimmer of hope in the face of this challenging condition.

Dr.Camel's Conclusion

This study provides exciting evidence for the potential of [targeted treprostinil delivery] as a therapeutic approach for [pulmonary arterial hypertension (PAH)]. It's like finding a hidden spring in the desert that can provide a direct source of nourishment and revitalization, offering a path towards improved health and well-being. This research represents a promising step forward in the development of more effective and targeted therapies for PAH.

Date :
  1. Date Completed 2022-04-26
  2. Date Revised 2022-04-26
Further Info :

Pubmed ID

35131313

DOI: Digital Object Identifier

10.1016/j.ejphar.2021.174700

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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