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Histamine H4 Receptor Agonism Induces Antitumor Effects in Human T-Cell Lymphoma.

Author: CerchiettiLeandro, ClauzureMariángeles, MedinaVanina A, PhillipJude M, RevueltaMaria V, Táquez DelgadoMónica A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

The histamine H4 receptor (H4R) is a potential target for the treatment of T-cell lymphoma (TCL). The authors investigated the expression and function of the H4R in three aggressive TCL cell lines. They found that all three cell lines expressed H4R and that histamine and specific H4R agonists significantly reduced cell viability. The authors also identified several FDA-approved drugs that enhanced the antitumor effects of histamine in TCL cells. These findings suggest that the H4R may be a promising therapeutic target for TCL.
Paper Details　
Original Abstract of the Article :
The discovery of the human histamine H4 receptor (H4R) has contributed to our understanding of the role of histamine in numerous physiological and pathological conditions, including tumor development and progression. The lymph nodes of patients with malignant lymphomas have shown to contain high lev...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836034/

データ提供：米国国立医学図書館（NLM）

A New Target: Histamine H4 Receptor Agonism in T-Cell Lymphoma Treatment

In the complex landscape of cancer research, identifying new therapeutic targets is paramount. This research delves into the potential of targeting the histamine H4 receptor (H4R) in the treatment of human T-cell lymphoma (TCL). The study demonstrates the expression of H4R in various TCL cell lines and investigates the effects of H4R agonists on cell viability. The results reveal significant antitumor effects of histamine and specific H4R agonists, suggesting a potential new avenue for TCL treatment. The study also explores the combination of H4R ligands with other FDA-approved compounds, demonstrating a favorable antitumor effect with certain drug combinations.

Histamine H4 Receptor: A Potential Therapeutic Target in T-Cell Lymphoma

This research, like a desert explorer uncovering hidden treasures, reveals the potential of targeting the H4R in TCL treatment. The study's findings demonstrate the significant antitumor effects of H4R agonists, suggesting a promising new avenue for exploring therapeutic strategies in this type of lymphoma. The study's exploration of drug combinations further enhances the potential of H4R-targeted therapies.

T-Cell Lymphoma Treatment: Embracing New Frontiers

The fight against cancer is an ongoing journey of discovery and innovation. This research encourages the exploration of novel therapeutic targets, like the H4R, in developing effective treatments for T-cell lymphoma. The study's findings highlight the potential of targeting specific receptors to achieve therapeutic benefits, offering new hope for individuals battling this challenging disease.

Dr. Camel's Conclusion

This research, like a shimmering oasis in the desert of cancer research, unveils the potential of targeting the histamine H4 receptor in the treatment of T-cell lymphoma. The study's findings provide a promising starting point for exploring new therapeutic strategies, opening up new avenues for addressing this challenging disease. As we continue to explore the complexities of cancer treatment, embracing innovative approaches and identifying novel targets is crucial in the ongoing pursuit of effective therapies.
Date :
  1. Date Completed 2022-03-09
  2. Date Revised 2022-03-09
Further Info :

Pubmed ID

35163302

DOI: Digital Object Identifier

PMC8836034

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Languages

English

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