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Effects of early-life antibiotics on the developing infant gut microbiome and resistome: a randomized trial.

Author: ArpKayleigh, BogaertDebby, ChuMei Ling J N, PlötzFrans B, ReymanMarta, SandersElisabeth A M, SchieringIrene, WatsonRebecca L, WillemsRob J L, de WaalWouter J, van HoutenMarlies A, van SchaikWillem

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Early-onset neonatal sepsis (sEONS) is a serious infection that can occur in the first week of life. This study investigated the effects of three commonly prescribed intravenous antibiotic combinations on gut microbiome development and antimicrobial resistance in infants with sEONS. The authors found that all three antibiotic combinations significantly altered the gut microbiome composition and increased the abundance of antimicrobial resistance genes. The effects were most pronounced with amoxicillin + cefotaxime and least pronounced with penicillin + gentamicin. These findings suggest that the choice of empirical antibiotics for sEONS can have a significant impact on the developing gut microbiome and the selection of antimicrobial resistance.
Paper Details　
Original Abstract of the Article :
Broad-spectrum antibiotics for suspected early-onset neonatal sepsis (sEONS) may have pronounced effects on gut microbiome development and selection of antimicrobial resistance when administered in the first week of life, during the assembly phase of the neonatal microbiome. Here, 147 infants born a...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850541/

データ提供：米国国立医学図書館（NLM）

Early Antibiotics and the Infant Gut Microbiome: A Balancing Act

The infant gut microbiome is a delicate ecosystem that plays a vital role in early development. This study explores the impact of early-life antibiotics on the developing gut microbiome and resistome in infants. The researchers conducted a randomized controlled trial involving 147 infants who required broad-spectrum antibiotics for suspected early-onset neonatal sepsis in their first week of life. They compared three different antibiotic combinations and analyzed the effects on gut microbiota and antimicrobial resistance genes. The study revealed that antibiotic treatment significantly altered the gut microbial community composition and antimicrobial resistance gene profile, with effects persisting for up to 12 months.

Antibiotic's Footprint: A Lasting Impact on the Gut Microbiome

This research demonstrates the profound impact of early-life antibiotics on the developing gut microbiome. The findings suggest that even short-term antibiotic use can disrupt the delicate balance of the gut microbiota, potentially leading to long-term consequences for infant health. This emphasizes the importance of judicious antibiotic use in infants, considering the potential risks and benefits.

Preserving the Gut Microbiome: A Crucial Element of Infant Health

Understanding the importance of the gut microbiome is essential for protecting infant health. This study highlights the need for minimizing unnecessary antibiotic use and exploring alternative strategies to manage infections in infants.

Dr.Camel's Conclusion

Imagine a camel trekking across the desert, carrying a delicate ecosystem of microbes within its digestive system. This study reveals how early antibiotics can disrupt this balance, potentially affecting the camel's overall health.

Date :
  1. Date Completed 2022-03-02
  2. Date Revised 2022-11-09
Further Info :

Pubmed ID

35173154

DOI: Digital Object Identifier

PMC8850541

Related Literature

Article Analysis
・Side Effects of amoxicillin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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