Mipomersen in Familial Hypercholesterolemia: An Update on Health-Related Quality of Life and Patient-Reported Outcomes.

Author: AgarwalaAnandita, AlurAnish, Chambergo-MichilotDiego, KulkarniSaneel

Paper Details 
Original Abstract of the Article :
Familial hypercholesterolemia (FH) is an autosomal dominant condition that leads to significantly elevated low-density lipoprotein cholesterol (LDL-C) levels and an elevated risk for cardiovascular disease. Mipomersen is an antisense oligonucleotide inhibitor targeted to apolipoprotein B-100 (apoB-1...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880726/

データ提供:米国国立医学図書館(NLM)

Mipomersen: A Targeted Approach to FH Management

Familial hypercholesterolemia (FH), a genetic condition leading to [high LDL-C levels] and increased risk for cardiovascular disease, presents a significant challenge for patients and healthcare professionals. This review focuses on [mipomersen], an [antisense oligonucleotide inhibitor] targeting [apolipoprotein B-100 (apoB-100) mRNA] for the treatment of FH. The authors discuss the mechanism of action, current evidence, limitations, adverse events, and impact on health-related quality of life associated with mipomersen. This review provides a comprehensive overview of this targeted therapeutic approach for FH.

Mipomersen: A Promising Weapon in the Fight Against FH

This review explores the potential of [mipomersen] as a targeted therapeutic agent for [familial hypercholesterolemia (FH)]. The authors discuss its mechanism of action, highlighting its ability to selectively inhibit the production of [apolipoprotein B-100 (apoB-100)], a key component of LDL-C. Their analysis of existing evidence suggests that mipomersen offers significant benefits in reducing LDL-C levels and potentially improving cardiovascular outcomes for patients with FH.

Navigating the Treatment Landscape: Choosing the Right Approach

FH presents a unique challenge for individuals seeking to manage their cholesterol levels and reduce their risk of cardiovascular disease. This review provides a detailed overview of [mipomersen], a targeted therapeutic agent that offers significant benefits for patients with FH. However, it's important to discuss the potential risks and benefits of mipomersen with a healthcare professional to determine the most appropriate treatment approach for your individual needs.

Dr.Camel's Conclusion

This review delves into the world of FH treatment, highlighting the potential of mipomersen as a targeted therapeutic agent. Just as a desert traveler might seek a specific source of water to quench their thirst, individuals with FH may benefit from a targeted approach to lowering LDL-C levels. By understanding the intricacies of mipomersen's mechanism of action and its potential impact on health, we can work collaboratively with healthcare professionals to make informed decisions about treatment plans and strive to achieve optimal health outcomes.

Date :
  1. Date Completed 2022-03-01
  2. Date Revised 2022-03-01
Further Info :

Pubmed ID

35221690

DOI: Digital Object Identifier

PMC8880726

Related Literature

SNS
PICO Info
in preparation
Languages

English

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