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Activation of Rictor/mTORC2 signaling acts as a pivotal strategy to protect against sensorineural hearing loss.

Author: AnYachun, ChaiRenjie, FuXiaolong, GaoJiangang, LiPeipei, LiuWenwen, SongYuning, SunXiaoyang, WangHaibo, YeChao, YueRongyu, ZhangAizhen, ZhangLinqing, ZhangYuan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Sirolimus, an mTOR inhibitor, protected mice against cocaine-induced hearing loss, but high doses caused substantial hearing loss. Inactivation of mTORC2, a key regulator of AKT/PKB signaling pathway, was the major driver underlying hearing loss. Selective activation of mTORC2 could protect mice from acoustic trauma and cisplatin-induced ototoxicity.
Paper Details　
Original Abstract of the Article :
The Food and Drug Administration–approved drug sirolimus, which inhibits mechanistic target of rapamycin (mTOR), is the leading candidate for targeting aging in rodents and humans. We previously demonstrated that sirolimus could treat ARHL in mice. In this study, we further demonstrate that sirolimu...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917383/

データ提供：米国国立医学図書館（NLM）

Unlocking the Potential of mTORC2 in Hearing Protection

The world of sirolimus, an FDA-approved drug, is full of intrigue. This powerful medication has been hailed as a potential weapon against aging in rodents and humans. But like a desert mirage, its effects can be complex and sometimes unpredictable. This research delves into the mysteries of sirolimus, exploring its impact on hearing loss and uncovering the pivotal role of a key player called mTORC2.

mTORC2: A Key Player in Hearing Protection

The researchers, like explorers mapping a hidden oasis, discovered that sirolimus, while effective in treating hearing loss in some cases, can actually worsen hearing at higher doses. They pinpointed the culprit: mTORC2, a protein complex that plays a crucial role in cell growth and survival. By silencing mTORC2, the researchers revealed its protective role in hearing, much like a guardian deity of the desert, shielding against the harsh elements. This discovery holds significant implications for future treatments, suggesting that targeting mTORC2 could be a promising strategy for preserving hearing.

Navigating the Complexities of mTORC2

The findings of this study shed light on the intricate interplay between mTORC2 and hearing loss. It's like navigating a desert landscape filled with hidden pathways, where a single wrong turn can lead to dangerous consequences. Understanding the role of mTORC2 in hearing protection is crucial for developing safe and effective therapies. Further research in this area could help to unlock the true potential of mTORC2, paving the way for new treatments that can protect our hearing and prevent the loss of this precious sense.

Dr. Camel's Conclusion

This study unveils the fascinating role of mTORC2 in hearing protection, a discovery that could revolutionize the treatment of hearing loss. It's like unearthing a hidden oasis in the vast desert of medical research, offering a refreshing and promising new approach to preserving our hearing.
Date :
  1. Date Completed 2022-03-15
  2. Date Revised 2022-07-12
Further Info :

Pubmed ID

35238644

DOI: Digital Object Identifier

PMC8917383

Related Literature

Article Analysis
・Side Effects of sirolimus
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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