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Meloxicam can Potentiate the Therapeutic Effects of Synchrotron Microbeam Radiation Therapy on High-Grade Glioma Bearing Rats.

Author: BouchetAudrey, Le Clec'hCéline, Le DucGéraldine, PelletierLaurent, RogalevLéonid

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Meloxicam, a non-steroidal anti-inflammatory drug, significantly extended the median survival of rats bearing intracranial 9L gliosarcoma treated with microbeam radiation therapy (MRT). Dual treatment led to last survivors until D90 and to tumor 9.5 times smaller than MRT alone.
Paper Details　
Original Abstract of the Article :
The microbeam radiation therapy (MRT), a spatially micro-fractionated synchrotron radiotherapy, leads to better control of incurable high-grade glioma than that obtained upon homogeneous radiotherapy. We evaluated the effect of meloxicam, a non-steroidal anti-inflammatory drug (NSAID), to increase t...See full text at original site
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引用元：
https://doi.org/10.1667/RADE-21-00107.1

データ提供：米国国立医学図書館（NLM）

Meloxicam: A Potential Booster for Microbeam Radiation Therapy

Microbeam radiation therapy (MRT), a precise and targeted approach to radiation therapy, offers a promising weapon against high-grade glioma, a formidable adversary in the battle against brain cancer. This research explores the potential of meloxicam, a non-steroidal anti-inflammatory drug (NSAID), to amplify the effectiveness of MRT. The study investigates the impact of meloxicam on the survival of rats with intracranial 9L gliosarcoma, a model for human brain cancer.

Enhanced Anti-Tumor Effect

The research reveals a synergistic effect of meloxicam and MRT in combating gliosarcoma. Rats treated with both meloxicam and MRT showed significantly extended survival times compared to those treated with MRT alone. Furthermore, the combination therapy led to a dramatic reduction in tumor size. These findings suggest that meloxicam may enhance the efficacy of MRT in treating high-grade glioma.

A Potential Breakthrough in Glioma Treatment

The results of this study offer a beacon of hope in the fight against brain cancer. The combination of MRT and meloxicam, a simple and easily administered drug, may offer a new and promising approach to treating this challenging disease. These findings warrant further investigation in human clinical trials.

Dr.Camel's Conclusion

This research reminds us that even in the vast and unforgiving desert of cancer research, there are still hidden oases of hope. The synergistic effect of meloxicam and MRT against gliosarcoma is exciting news. This study, like a desert bloom, offers a glimmer of promise for future treatments.

Date :
  1. Date Completed 2022-06-06
  2. Date Revised 2022-06-10
Further Info :

Pubmed ID

35245385

DOI: Digital Object Identifier

10.1667/RADE-21-00107.1

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Article Analysis
・Effects of meloxicam
SNS
PICO Info
in preparation
Languages

English

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