Anti-aging effects of chlorpropamide depend on mitochondrial complex-II and the production of mitochondrial reactive oxygen species.

Author: BaoKeting, FengJiali, HuZelan, HuangYunyuan, LiJian, LiuWenwen, MaoZhifan, MoskalevAlexey, SunTianyue

Paper Details 
Original Abstract of the Article :
Sulfonylureas are widely used oral anti-diabetic drugs. However, its long-term usage effects on patients' lifespan remain controversial, with no reports of influence on animal longevity. Hence, the anti-aging effects of chlorpropamide along with glimepiride, glibenclamide, and tolbutamide were studi...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897034/

データ提供:米国国立医学図書館(NLM)

Unveiling the Anti-aging Potential of Sulfonylureas

This research delves into the intriguing world of anti-aging therapies, focusing on sulfonylureas, a class of drugs primarily used to treat diabetes. It's like a treasure hunt, uncovering the hidden potential of these medications beyond their original purpose. The study found that chlorpropamide, a type of sulfonylurea, exhibited anti-aging effects in various models, including worms, human cells, and mice. This finding is significant as it suggests a potential new application for these commonly used medications.

A New Perspective on Sulfonylurea Medications

This study sheds light on the potential anti-aging benefits of sulfonylureas. It's like discovering a hidden oasis in the desert, offering a novel approach to combatting the aging process. The findings suggest that chlorpropamide may have a direct or indirect effect on mitochondria, leading to increased levels of mtROS, a molecule that plays a role in regulating lifespan.

Exploring the Potential of Anti-aging Therapies

This research opens up new avenues for exploring the potential of anti-aging therapies. It's like opening a new chapter in the book of longevity, searching for ways to extend lifespan and improve quality of life. This study is a valuable step in the ongoing quest to understand the aging process and develop therapies to slow or reverse its effects.

Dr.Camel's Conclusion

This study is a fascinating example of how scientific research can lead to unexpected discoveries. It's like finding a hidden gem in the desert, revealing the potential of existing medications for new applications. This research opens doors to a new understanding of the aging process and the potential of existing medications to influence lifespan.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-03-09
Further Info :

Pubmed ID

35256938

DOI: Digital Object Identifier

PMC8897034

Related Literature

SNS
PICO Info
in preparation
Languages

English

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