A double-blind randomised placebo-controlled trial investigating the effects of lesogaberan on the objective cough frequency and capsaicin-evoked coughs in patients with refractory chronic cough.

Author: Al-ShekllyBashar, BadriHuda, CanningBrendan J, DentonDimitra, DockryRachel J, EscottK Jane, GibbardCarmen, HoltAlison, HoltKimberley, HoughtonLesley, LeeAugustine, LeeTheresa, McGuinessKevin, SatiaImran, SmithJacky A, TreadwaySam, WhorwellPeter, WilkinsonGreame

Paper Details 
Original Abstract of the Article :
Label="Objective" NlmCategory="UNASSIGNED">Baclofen is a centrally acting &#947;-aminobutyric acid type B (GABA<sub>B</sub>) receptor agonist which reduces gastro-oesophageal reflux and suppresses the cough reflex; however, central nervous system side-effects limit its use. Lesogaberan is a novel pe...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918934/

データ提供:米国国立医学図書館(NLM)

Lesogaberan: A Novel Treatment for Refractory Chronic Cough

The unrelenting torment of [refractory chronic cough] can be a debilitating experience, leaving patients feeling exhausted and isolated. This study explores the potential of [lesogaberan], a novel medication, to alleviate this distressing condition. It's like searching for a hidden oasis in the vast desert of cough-related ailments, hoping to find a source of relief and solace.

The study, a double-blind randomized placebo-controlled trial, investigated the effects of lesogaberan on cough frequency and capsaicin-evoked coughs in patients with refractory chronic cough. The results, while still preliminary, suggest that lesogaberan may hold promise as a treatment option for this challenging condition. It's like discovering a new medicinal herb in the desert, offering a potential solution to a persistent ailment.

Lesogaberan: A Potential New Weapon in the Fight Against Chronic Cough

This study provides a glimmer of hope for patients with chronic cough. Lesogaberan, with its unique mechanism of action, may offer a new avenue for managing this debilitating condition, potentially improving quality of life and reducing the burden of cough.

Navigating the Treatment Landscape: A Careful Approach to New Medications

It's important to remember that this study is still in its early stages and further research is needed to fully evaluate the effectiveness and safety of lesogaberan. As with any new medication, a careful and personalized approach is essential, considering individual patient needs and potential risks.

Dr.Camel's Conclusion

This study offers an exciting glimpse into the potential of lesogaberan to alleviate refractory chronic cough. While further research is needed, it provides a beacon of hope for patients seeking relief from this debilitating condition. The ongoing exploration of novel treatments for chronic cough is a testament to the relentless pursuit of better health and well-being.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-04-02
Further Info :

Pubmed ID

35295236

DOI: Digital Object Identifier

PMC8918934

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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