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A pharmacogenomic assessment of psychiatric adverse drug reactions to levetiracetam.

Author: , BerkovicSamuel F, BobbiliDheeraj, CampbellCiarán, CavalleriGianpiero L, CotterDavid, DelantyNorman, DepondtChantal, DohertyColin P, GoldsteinDavid B, HeinzenErin L, KoelemanBobby P, KrauseRoland, KunzWolfram S, LercheHolger, McCormackMark, O'BrienTerence, PatelSonn, SanderJosemir W, SchefferIngrid E, SillsGraeme J, SisodiyaSanjay M, StapletonCaragh, StefanssonHreinn, StefanssonKari, StrianoPasquale, ZaraFederico

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the genetic contribution to psychiatric and behavioral adverse drug reactions (ADRs) associated with levetiracetam (LEV).
Paper Details　
Original Abstract of the Article :
Levetiracetam (LEV) is an effective antiseizure medicine, but 10%-20% of people treated with LEV report psychiatric side-effects, and up to 1% may have psychotic episodes. Pharmacogenomic predictors of these adverse drug reactions (ADRs) have yet to be identified. We sought to determine the contribu...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321556/

データ提供：米国国立医学図書館（NLM）

Pharmacogenomics and Psychiatric Side Effects of Levetiracetam

This research explores the fascinating world of [pharmacogenomics] and its potential role in predicting psychiatric side effects of [levetiracetam]. It's like sifting through the sands of the genetic code to understand how individuals react differently to medications. This study aims to identify genetic variations that may contribute to [psychiatric adverse drug reactions] associated with [levetiracetam], a medication commonly used for epilepsy.

Unveiling the Genetic Roots of Psychiatric Side Effects

This study aims to understand the genetic factors that influence the risk of [psychiatric adverse drug reactions] associated with [levetiracetam]. This research could lead to personalized medicine approaches where genetic testing helps guide medication choices, potentially reducing the risk of adverse reactions and improving patient outcomes.

Navigating the Complexities of Epilepsy Treatment

This research underscores the complexity of epilepsy treatment and the importance of considering individual differences. By identifying genetic factors that may contribute to [psychiatric adverse drug reactions], this research could pave the way for more personalized and effective treatment strategies. It's like tailoring a camel caravan route to the specific needs of each traveler.

Dr.Camel's Conclusion

This study represents a step toward a future where medications are tailored to the individual's genetic makeup. By understanding the genetic underpinnings of [psychiatric adverse drug reactions], we can make treatment safer and more effective for those living with epilepsy. It's a journey of discovery that could transform the landscape of medical practice, paving the way for a more personalized and effective healthcare system.
Date :
  1. Date Completed 2022-06-06
  2. Date Revised 2023-03-16
Further Info :

Pubmed ID

35298028

DOI: Digital Object Identifier

PMC9321556

Related Literature

Article Analysis
・Side Effects of levetiracetam
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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