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Blockade of M4 muscarinic receptors on striatal cholinergic interneurons normalizes striatal dopamine release in a mouse model of TOR1A dystonia.

Author: DonsanteYuping, DownsAnthony M, HessEllen J, JinnahH A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the mechanism of action of trihexyphenidyl (THP), a non-selective muscarinic receptor (mAChR) antagonist, in treating dystonia associated with TOR1A. The study found that THP acts in part at M4 mAChR on striatal cholinergic interneurons to enhance dopamine release.
Paper Details　
Original Abstract of the Article :
Trihexyphenidyl (THP), a non-selective muscarinic receptor (mAChR) antagonist, is commonly used for the treatment of dystonia associated with TOR1A, otherwise known as DYT1 dystonia. A better understanding of the mechanism of action of THP is a critical step in the development of better therapeutics...See full text at original site
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引用元：
https://doi.org/10.1016/j.nbd.2022.105699

データ提供：米国国立医学図書館（NLM）

M4 Muscarinic Receptors and Striatal Dopamine Release in Dystonia

This study investigates the role of M4 muscarinic receptors in regulating striatal dopamine release in a mouse model of TOR1A dystonia. It's like delving into the intricate circuitry of the brain, exploring the mechanisms that underlie movement disorders. The researchers found that blockade of M4 receptors on striatal cholinergic interneurons normalizes dopamine release, suggesting a potential therapeutic target for treating dystonia. This study provides valuable insights into the complex neurobiology of dystonia and offers a promising new avenue for drug development.

Unlocking the Brain's Secrets: A New Path for Dystonia Treatment

The study's findings offer hope for individuals struggling with TOR1A dystonia. It's like discovering a hidden pathway in the complex desert of neurological disorders. The researchers' work reveals the importance of M4 muscarinic receptors in regulating dopamine release and suggests that targeting these receptors could provide a new therapeutic approach for treating this movement disorder.

Navigating the Desert of Movement Disorders

This research highlights the importance of understanding the intricate workings of the brain in developing effective treatments for neurological disorders. It's like navigating a vast desert of neurological research, where every discovery can lead to new insights and potential therapies. The study's findings offer a promising new avenue for treating dystonia, underscoring the value of continued research and innovation in this field.

Dr.Camel's Conclusion

This study unveils the intricate role of M4 muscarinic receptors in regulating dopamine release in a mouse model of TOR1A dystonia. It's like uncovering a hidden oasis in the vast desert of neurological research, revealing a potential new target for treating this movement disorder. The findings offer hope for individuals struggling with dystonia and highlight the importance of continued research to understand the complex neurobiology of these conditions.

Date :
  1. Date Completed 2022-04-20
  2. Date Revised 2023-07-01
Further Info :

Pubmed ID

35314320

DOI: Digital Object Identifier

10.1016/j.nbd.2022.105699

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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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