Effects of Injection Volume and Route of Administration on Dolutegravir In Situ Forming Implant Pharmacokinetics.

Author: BenhabbourSoumya Rahima, CottrellMackenzie L, DaytonPaul A, HowardSarah Anne, JoinerJordan B, KashubaAngela D M, KingJasmine L, ShrivastavaRoopali

Paper Details 
Original Abstract of the Article :
Due to the versatility of the in situ forming implant (ISFI) drug delivery system, it is crucial to understand the effects of formulation parameters for clinical translation. We utilized ultrasound imaging and pharmacokinetics (PK) in mice to understand the impact of administration route, injection ...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8948873/

データ提供:米国国立医学図書館(NLM)

Dolutegravir In Situ Forming Implants: A New Oasis in Drug Delivery

Drug delivery systems are constantly evolving, seeking new and innovative ways to deliver medications effectively and safely. This study explores the use of dolutegravir in situ forming implants (ISFIs) as a novel drug delivery method. Researchers investigated the impact of formulation parameters, such as injection volume and route of administration, on the pharmacokinetics of dolutegravir ISFIs in mice. They found that ISFIs exhibited prolonged drug release, with dolutegravir concentrations exceeding the necessary levels for efficacy throughout the study period. This research suggests that dolutegravir ISFIs hold promise as a new and effective drug delivery system.

A New Oasis in Drug Delivery: In Situ Forming Implants

This research highlights the potential of ISFIs as a versatile and effective drug delivery platform. The ability to adjust formulation parameters to optimize drug release and duration of action offers significant advantages for managing various conditions. Think of it as finding a new oasis in a desert – ISFIs provide a reliable and sustainable source of medication, ensuring consistent drug levels for optimal therapeutic effect.

The Desert of Drug Delivery: Exploring New Frontiers

This research is a testament to the ongoing efforts to improve drug delivery systems. ISFI technology holds promise for a wide range of applications, offering a potentially safer and more effective way to deliver medications. As we continue to explore the vast desert of drug delivery, researchers are constantly seeking new oases of knowledge and innovation, leading to more effective and personalized treatment strategies.

Dr.Camel's Conclusion

This research is a beacon of hope in the desert of drug delivery. Dolutegravir ISFIs offer a promising new approach for managing a variety of conditions, providing a reliable and effective way to deliver medication. As we continue to explore this exciting frontier, ISFI technology has the potential to transform the way we treat diseases and improve the lives of countless individuals.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-03-29
Further Info :

Pubmed ID

35335991

DOI: Digital Object Identifier

PMC8948873

Related Literature

SNS
PICO Info
in preparation
Languages

English

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