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In silico analysis of SARS-CoV-2 proteins as targets for clinically available drugs.

Author: CarlsonHeather A, ChanWallace K B, OlsonKeith M, SextonJonathan Z, TraynorJohn R, WotringJesse W

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

This study utilizes a multi-target and multi-ligand virtual screening method to identify FDA-approved drugs with potential activity against SARS-CoV-2. The findings highlight six potential drug candidates for further investigation.
Paper Details　
Original Abstract of the Article :
The ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires treatments with rapid clinical translatability. Here we develop a multi-target and multi-ligand virtual screening method to identify FDA-approved drugs with potential activity against SARS-CoV-2 at t...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963407/

データ提供：米国国立医学図書館（NLM）

In Silico Analysis of SARS-CoV-2 Proteins as Targets for Clinically Available Drugs

The field of [drug repurposing] plays a crucial role in responding to emerging health threats like the [COVID-19 pandemic]. This study used a [multi-target and multi-ligand virtual screening method] to identify [FDA-approved drugs] with potential activity against [SARS-CoV-2] proteins. The researchers identified [17 'high-confidence' and 97 'medium-confidence' drug-site pairs], suggesting potential targets for drug repurposing.

Potential Drug Targets for SARS-CoV-2

This study provides a valuable resource for [drug repurposing efforts] in the fight against COVID-19. The identified [drug-site pairs] suggest potential avenues for [rapidly evaluating existing medications] for their effectiveness against SARS-CoV-2.

The Importance of Drug Repurposing

Just as a desert traveler might use a tool for multiple purposes, [drug repurposing] allows us to leverage existing knowledge and resources to develop new treatment strategies. This approach can accelerate the development of [effective treatments] for emerging diseases like COVID-19.

Dr.Camel's Conclusion

The search for effective treatments for COVID-19 continues. This study provides a valuable roadmap for [drug repurposing efforts], highlighting promising candidates for further investigation and potential clinical trials. By exploring [existing medications] for new applications, we can potentially find solutions to pressing health challenges.

Date :
  1. Date Completed 2022-04-04
  2. Date Revised 2023-11-03
Further Info :

Pubmed ID

35351926

DOI: Digital Object Identifier

PMC8963407

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English

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