Paper Details 
Original Abstract of the Article :
Sjogren's syndrome and radiation therapy for head and neck cancers are often accompanied by xerostomia. Oral pilocarpine (PCP) to treat xerostomia produces systemic side effects, such as runny nose and lacrimation. To improve the therapeutic efficacy of PCP and reduce the aforementioned side effects...See full text at original site
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引用元:
https://doi.org/10.1248/bpb.b21-00763

データ提供:米国国立医学図書館(NLM)

Topical Xerostomia Treatment with Hyaluronate Sheets

Xerostomia, or dry mouth, is a common symptom associated with conditions like Sjögren's syndrome and radiation therapy for head and neck cancers. This study explores a novel topical delivery system for pilocarpine (PCP), a medication used to treat xerostomia, using freeze-dried hyaluronic acid (HA) sheets. The researchers found that buccal application of HA sheets containing PCP resulted in increased PCP concentration in the oral submucosal tissue, while minimizing systemic side effects. This research suggests that HA sheets could offer a more effective and targeted approach to treating xerostomia.

Targeting Dry Mouth: A New Approach to Treatment

This study presents a promising new strategy for treating xerostomia, a condition that can significantly impact quality of life. Similar to a camel finding a refreshing oasis in a dry desert, HA sheets containing PCP offer a localized and targeted approach to delivering medication, potentially improving effectiveness and reducing side effects. This research opens up new possibilities for managing xerostomia and improving the well-being of patients.

Finding Relief from Dry Mouth: A Look at Treatment Options

The study highlights the potential of HA sheets as a novel delivery system for PCP, a medication commonly used to treat xerostomia. This approach could offer patients a more effective and targeted treatment option, potentially minimizing systemic side effects associated with oral administration. As always, it is important to consult with healthcare professionals to discuss the most suitable treatment options based on individual needs and medical history.

Dr. Camel's Conclusion

This research explores a novel topical delivery system for pilocarpine, offering a promising new approach to the treatment of xerostomia. The study's findings suggest that HA sheets could provide a more effective and targeted delivery method, potentially improving patient outcomes and minimizing side effects. This research exemplifies the ongoing quest for innovative treatment solutions in the field of oral health.

Date :
  1. Date Completed 2022-04-05
  2. Date Revised 2022-04-05
Further Info :

Pubmed ID

35370264

DOI: Digital Object Identifier

10.1248/bpb.b21-00763

Related Literature

SNS
PICO Info
in preparation
Languages

English

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