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Comparison of the Effectiveness and Safety of d-Penicillamine and Zinc Salt Treatment for Symptomatic Wilson Disease: A Systematic Review and Meta-Analysis.

Author: BaiLi, ChenXinyue, DuanZhongping, HouWei, HuZhongjie, LiangChen, TangShan, ZhangWei, ZhaoJing, ZhengSujun

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This meta-analysis evaluated the efficacy and safety of d-penicillamine and zinc salts in treating Wilson disease (WD). The analysis found that both treatments were effective, but d-penicillamine was associated with a higher risk of adverse effects and neurological deterioration. The authors recommend caution when interpreting these findings.
Paper Details　
Original Abstract of the Article :
<b>Background:</b> Pharmacological therapy is currently the main treatment method for patients with Wilson disease (WD). We aimed to evaluate the efficacy and safety of the common treatment regimens in these patients. <b>Methods:</b> We conducted a systemic review and meta-analysis by searching mul...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8975209/

データ提供：米国国立医学図書館（NLM）

d-Penicillamine vs. Zinc Salts for Wilson Disease: A Systematic Review and Meta-Analysis

Wilson disease (WD) is a rare genetic disorder that can feel like a desert of uncertainty for patients. This systematic review and meta-analysis compare the efficacy and safety of two common treatment regimens for WD: d-penicillamine and zinc salts. The authors aimed to assess the effectiveness of each treatment in improving symptoms and reducing the risk of adverse effects.

Navigating the Wilson Disease Desert: Comparing Treatments

The analysis found that both d-penicillamine and zinc salts showed a high overall improved rate in symptomatic WD patients. However, patients receiving d-penicillamine experienced a significantly higher incidence of adverse effects and neurological deterioration compared to those receiving zinc salts. There was no significant difference in treatment efficiency between the two regimens for hepatic WD, but zinc salts appeared to be more effective for neurological WD.

Choosing the Right Path in the Wilson Disease Desert

This meta-analysis highlights the importance of carefully considering the risks and benefits of different treatment options for WD. While both d-penicillamine and zinc salts can be effective, zinc salts appear to offer a safer profile, particularly for patients with neurological WD. Consulting with a healthcare professional is crucial to determine the best treatment for your individual needs and to manage potential side effects.

Dr.Camel's Conclusion

This meta-analysis provides valuable insights into the treatment landscape for Wilson disease. While both d-penicillamine and zinc salts can be effective, zinc salts appear to offer a safer profile, particularly for neurological WD. The choice of treatment should be made in collaboration with a healthcare professional, taking into account the specific needs and potential risks associated with each option.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-04-05
Further Info :

Pubmed ID

35370752

DOI: Digital Object Identifier

PMC8975209

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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