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Effect of FT218, a Once-Nightly Sodium Oxybate Formulation, on Disrupted Nighttime Sleep in Patients with Narcolepsy: Results from the Randomized Phase III REST-ON Trial.

Author: BoganRichard, CorserBruce C, DauvilliersYves, DubowJordan, KushidaClete, RosenbergRussell, RothThomas, SeidenDavid, ThorpyMichael J

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Sodium oxybate is the gold standard for narcolepsy-related sleep disruption. Its short half-life requires twice-nightly dosing, leading to inconvenience. A novel extended-release, once-nightly sodium oxybate formulation (ON-SXB; FT218) is under review for narcolepsy treatment, offering potential convenience and improved adherence for patients.
Paper Details　
Original Abstract of the Article :
Sodium oxybate has been recognized as a gold standard for the treatment of disrupted nighttime sleep due to narcolepsy. Its short half-life and immediate-release formulation require patients to awaken 2.5-4 h after their bedtime dose to take a second dose. A novel extended-release, once-nightly sodi...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8994715/

データ提供：米国国立医学図書館（NLM）

A New Dawn in the Narcolepsy Desert: One-Nightly Sodium Oxybate

In the vast and often misunderstood [narcolepsy] desert, we find [disrupted nighttime sleep], a condition as debilitating as a sandstorm. This study delves into the world of [sodium oxybate] and its potential to bring [relief] to those struggling with [narcolepsy]. It's like seeking a safe haven from the relentless heat of this disease.

One-Nightly Sodium Oxybate: A Beacon in the Desert of Narcolepsy

The study highlights the [potential benefits] of a [novel extended-release, once-nightly sodium oxybate formulation] for [adults with narcolepsy]. It's like discovering a new type of oasis, offering a more convenient and effective solution to the challenges of narcolepsy. The results suggest that this new formulation may offer a more manageable treatment option, reducing the need for [multiple nighttime doses].

Navigating the Narcolepsy Desert with More Ease

This research presents a promising new direction in the management of [narcolepsy]. It's like finding a more reliable camel to navigate the desert, offering greater comfort and a smoother journey. As we continue to explore the complex landscape of narcolepsy, it's encouraging to see new tools and strategies emerging to help those affected by this condition.

Dr.Camel's Conclusion

This study provides a ray of hope in the [narcolepsy] desert, offering a new approach to managing this challenging condition. It's a reminder that even in the most challenging environments, there is always the potential for innovation and progress. We must continue to explore new paths and seek better solutions for those struggling with narcolepsy.

Date :
  1. Date Completed 2022-04-12
  2. Date Revised 2022-05-06
Further Info :

Pubmed ID

35380374

DOI: Digital Object Identifier

PMC8994715

Related Literature

Article Analysis
・Effects of sodium oxybate
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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