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Effectiveness of nonsteroidal mineralocorticoid receptor antagonists in patients with diabetic kidney disease.

Author: BakrisGeorge, LermaEdgar, WhiteWilliam B

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Nonsteroidal mineralocorticoid receptor antagonists (MRAs) are a new class of drugs developed for the treatment of diabetic kidney disease (DKD). Finerenone, the first nonsteroidal MRA approved in the US, has been shown to slow CKD progression without inducing marked antihypertensive effects. Esaxerenone, another nonsteroidal MRA, is licensed in Japan for treating hypertension. These drugs have the potential to expand the therapeutic options for patients with DKD.
Paper Details　
Original Abstract of the Article :
Nonsteroidal mineralocorticoid receptor antagonists (MRAs) are a new class of drugs developed to address the medical need for effective and safer treatment to protect the kidney and the heart in patients with diabetic kidney disease (DKD). There are several drugs within this class at varying stages ...See full text at original site
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引用元：
https://doi.org/10.1080/00325481.2022.2060598

データ提供：米国国立医学図書館（NLM）

Effectiveness of nonsteroidal mineralocorticoid receptor antagonists in patients with diabetic kidney disease

The vast desert of [diabetic kidney disease (DKD)] research presents a challenging landscape, with researchers seeking effective treatments to protect the kidneys and heart in patients with this debilitating condition. This study explores the potential benefits of [nonsteroidal mineralocorticoid receptor antagonists (MRAs)] in managing DKD.

Nonsteroidal MRAs: A New Frontier in DKD Treatment

The researchers discuss the emergence of nonsteroidal MRAs as a new class of drugs for treating DKD. These drugs offer a potential alternative to traditional [steroidal MRAs], which can have significant side effects. The study highlights the benefits of nonsteroidal MRAs in [slowing CKD progression] without inducing marked antihypertensive effects.

Hope for DKD Patients

The study's findings offer hope for patients with DKD by providing new treatment options that may be more effective and safer than traditional therapies. The development of nonsteroidal MRAs represents a significant advancement in DKD treatment, offering a potential path toward improved kidney and heart health for individuals with this challenging condition.

Dr. Camel's Conclusion

This study provides a comprehensive overview of the emerging field of [nonsteroidal MRAs] in treating DKD. The researchers' analysis of the pharmacological and clinical differences between nonsteroidal and steroidal MRAs highlights the potential for these new drugs to revolutionize DKD treatment. The study's findings offer a glimmer of hope for patients with DKD, providing a potential path toward improved kidney and heart health. As Dr. Camel, I am always excited to witness the advancements in medical research, particularly those that offer new hope for individuals facing chronic and debilitating conditions. The development of nonsteroidal MRAs represents a significant step forward in the ongoing battle against DKD, offering a potential for a more positive future for patients with this condition.
Date :
  1. Date Completed 2023-03-24
  2. Date Revised 2023-03-24
Further Info :

Pubmed ID

35392754

DOI: Digital Object Identifier

10.1080/00325481.2022.2060598

SNS
PICO Info
in preparation
Languages

English

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