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The hsa-miR-214-3p/ATGL axis regulates aberrant lipolysis to promote acute myeloid leukemia progression via PPARα in vitro.

Author: LiDongyi, LiYifei, LouShifeng, WuWu, YuanShiyi, ZhangPing, ZhangYing, ZhouJingwen

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

hsa-miR-214-3p regulates aberrant lipolysis by promoting ATGL expression, contributing to acute myeloid leukemia (AML) progression through the PPARα pathway. This study investigated the role of lipid metabolism in AML progression, finding that ATGL, an enzyme involved in lipolysis, is overexpressed in AML cell lines and promotes cell growth. hsa-miR-214-3p was identified as a suppressor of ATGL, acting through the hsa-miR-214-3p/ATGL/PPARα pathway.
Paper Details　
Original Abstract of the Article :
Aberrant lipid metabolism is a hallmark of malignant cancers. Recent studies have shown that abnormal activation of the lipolysis pathway might contribute to acute myeloid leukemia (AML) progression. However, the molecular mechanism through which lipid metabolism mediates AML progression is unknown....See full text at original site
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引用元：
https://doi.org/10.1016/j.bbrc.2022.03.140

データ提供：米国国立医学図書館（NLM）

Acute Myeloid Leukemia: A Journey Through the Desert of Aberrant Lipolysis

Acute myeloid leukemia (AML) is a serious blood cancer characterized by abnormal cell growth and development. This study investigates the role of aberrant lipolysis, the breakdown of fat, in AML progression. Imagine a traveler lost in a desert, where the landscape is constantly shifting and the resources are scarce. Similarly, AML cells often exhibit aberrant metabolic processes, leading to uncontrolled growth and survival. This research explores the connection between lipolysis and AML progression, shedding light on the complexities of cancer metabolism.

A New Target in the Desert: The hsa-miR-214-3p/ATGL Axis

The study identifies a potential target for AML therapy: the hsa-miR-214-3p/ATGL axis. The researchers found that hsa-miR-214-3p, a microRNA, regulates the expression of ATGL (adipose triglyceride lipase), an enzyme involved in lipolysis. They discovered that increased ATGL expression promotes the growth of AML cells, suggesting that targeting this pathway could offer a new avenue for treatment. These findings highlight the importance of understanding the intricate metabolic processes involved in cancer development and progression, opening new avenues for targeted therapy.

Navigating the Desert of Cancer Metabolism: A New Path to Treatment

The study's findings offer a glimpse into the potential of targeting aberrant lipolysis in AML treatment. Dr. Camel believes that by understanding the complex interplay between metabolic pathways and cancer progression, we can develop more effective and targeted therapies to combat this challenging disease. This research is a testament to the ongoing pursuit of new solutions in the desert of cancer research.

Dr.Camel's Conclusion

This study highlights the critical role of aberrant lipolysis in AML progression, identifying a promising new target for therapeutic intervention. Dr. Camel believes that by navigating the desert of cancer metabolism and understanding the intricate metabolic pathways involved in cancer development, we can develop more effective and personalized treatments for AML and other cancers.

Date :
  1. Date Completed 2022-04-28
  2. Date Revised 2022-05-31
Further Info :

Pubmed ID

35395550

DOI: Digital Object Identifier

10.1016/j.bbrc.2022.03.140

Related Literature

Article Analysis
・Causes of acute myeloid leukemia (aml)
SNS
PICO Info
in preparation
Languages

English

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