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Biochemical profiling of lead-intoxicated impaired lipid metabolism and its amelioration using plant-based bioactive compound.

Author: AkashMuhammad Sajid Hamid, QaderAbdul, RehmanKanwal

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effects of lead (Pb) on lipid metabolism and the potential therapeutic benefits of resveratrol. Pb exposure significantly disrupted lipid profiles and reduced antioxidant enzyme levels in rats, leading to lipid peroxidation. Resveratrol was found to be effective in ameliorating these effects, demonstrating its therapeutic potential for Pb-induced lipid metabolism impairment.
Paper Details　
Original Abstract of the Article :
The aim of this study was to investigate the lead (Pb)-induced lipid metabolism impairment and its amelioration using plant-based therapeutic interventions. Pb-induced hepatotoxicity can disturb the normal levels of natural antioxidant enzymes including glutathione (GSH) and superoxide dismutase (SO...See full text at original site
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引用元：
https://doi.org/10.1007/s11356-022-20069-5

データ提供：米国国立医学図書館（NLM）

Lead Toxicity and Lipid Metabolism: A Plant-Based Solution

This research explores the harmful effects of lead toxicity on lipid metabolism, a crucial process involved in energy production and cell function. The researchers investigated the effects of lead acetate (PbAc) on various lipid parameters in rats, demonstrating the potential for lead exposure to disrupt normal lipid metabolism. The study also explored the protective effects of resveratrol, a plant-based compound, against lead-induced lipid metabolism impairment. This research provides valuable insights into the potential health risks associated with lead exposure and highlights the potential benefits of plant-based interventions for mitigating lead toxicity.

Lead's Devious Effects: Disrupting Lipid Balance

The study demonstrates that lead exposure can significantly disrupt lipid metabolism, leading to imbalances in cholesterol levels, triglyceride levels, and the production of various lipoprotein fractions. This disruption can have far-reaching consequences for overall health, potentially contributing to cardiovascular disease and other health problems.

Resveratrol: A Plant-Based Protector Against Lead Toxicity

The study found that resveratrol effectively mitigated the adverse effects of lead exposure on lipid metabolism. This finding highlights the potential of natural compounds like resveratrol for protecting against the harmful effects of heavy metal toxicity and promoting overall health.

Dr. Camel's Conclusion

Imagine a desert oasis, a source of life and sustenance in a harsh landscape. Lead exposure, like a scorching desert wind, can disrupt the delicate balance of lipid metabolism. Resveratrol, like a refreshing oasis, offers a natural antidote, mitigating the harmful effects of lead toxicity and promoting a healthier lipid balance. This study underscores the importance of protecting ourselves from environmental toxins and exploring the potential of plant-based interventions for promoting overall well-being.
Date :
  1. Date Completed 2022-09-01
  2. Date Revised 2022-09-06
Further Info :

Pubmed ID

35420345

DOI: Digital Object Identifier

10.1007/s11356-022-20069-5

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Languages

English

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