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Effects of ivacaftor on systemic inflammation and the plasma proteome in people with CF and G551D.

Author: DeBoerEmily M, HeltsheSonya L, HoppeJordana E, Kirk HarrisJ, RoweSteven M, SagelScott D, WagnerBrandie D

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Ivacaftor is a drug that helps people with cystic fibrosis who have the G551D mutation. This study looked at how ivacaftor affects the body, particularly inflammation, growth, and certain proteins.
Paper Details　
Original Abstract of the Article :
Ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator for people with CF and the G551D mutation. We aimed to investigate the biology of CFTR modulation and systemic effects of CFTR restoration by examining changes in circulating measurements of inflammation and growth...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
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引用元：
https://pubmed.ncbi.nlm.nih.gov/35440409

データ提供：米国国立医学図書館（NLM）

Ivacaftor: Impact on Systemic Inflammation and the Plasma Proteome in CF Patients

This research, like a camel navigating the shifting sands of cystic fibrosis (CF) research, investigates the effects of ivacaftor, a CFTR potentiator, on systemic inflammation and the plasma proteome in patients with the G551D mutation. The researchers aim to understand the biological mechanisms of CFTR modulation and the systemic effects of restoring CFTR function.

Ivacaftor: A Potential Modifier of Systemic Inflammation in CF

This study, like a hidden spring in the desert of CF research, provides insights into the potential impact of ivacaftor on systemic inflammation and the plasma proteome in patients with the G551D mutation. The findings offer a glimpse into the complex interplay between CFTR restoration and its systemic effects.

Managing CF: A Multifaceted Approach

The study underscores the importance of considering the systemic effects of CFTR modulators in managing CF. It highlights the need for comprehensive monitoring and personalized treatment approaches to optimize patient outcomes.

Dr.Camel's Conclusion

This research offers valuable insights into the systemic effects of ivacaftor in CF patients with the G551D mutation. It provides a foundation for further research into the complex interplay between CFTR modulation, inflammation, and the plasma proteome.

Date :
  1. Date Completed 2022-12-08
  2. Date Revised 2023-11-02
Further Info :

Pubmed ID

35440409

DOI: Digital Object Identifier

NIHMS1799165

Related Literature

Article Analysis
・Effects of ivacaftor
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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