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Evaluation of Individual Items of the Patient Health Questionnaire (PHQ-9) and Montgomery-Asberg Depression Rating Scale (MADRS) in Adults with Treatment-Resistant Depression Treated with Esketamine Nasal Spray Combined with a New Oral Antidepressant.

Author: CooperKimberly, DrevetsWayne C, FlodenLysbeth, HudgensStacie, JamiesonCarol, PopovaVanina, SinghJaskaran

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated which specific symptoms of depression improved in patients with treatment-resistant depression (TRD) who received esketamine nasal spray in combination with oral antidepressants compared to those who received a placebo. The study found that esketamine was associated with improvements in certain symptoms, but not others.
Paper Details　
Original Abstract of the Article :
The objective of this study was to determine which symptoms measured by the Patient Health Questionnaire (PHQ-9) and Montgomery-Asberg Depression Rating Scale (MADRS) improve in those treated with esketamine nasal spray in combination with oral antidepressant (AD) compared with those treated with pl...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166828/

データ提供：米国国立医学図書館（NLM）

Evaluation of Individual Items of the Patient Health Questionnaire (PHQ-9) and Montgomery-Asberg Depression Rating Scale (MADRS) in Adults with Treatment-Resistant Depression Treated with Esketamine Nasal Spray Combined with a New Oral Antidepressant

Treatment-resistant depression (TRD), a challenging mental health condition, often requires innovative approaches to manage symptoms. This research explores the effectiveness of esketamine nasal spray, a novel treatment for TRD, when combined with oral antidepressants. The study evaluated the impact of esketamine on specific symptoms of depression, measured by the PHQ-9 and MADRS scales. The findings suggest that esketamine, when combined with oral antidepressants, can effectively improve certain symptoms of depression, indicating its potential as an adjunctive therapy for TRD.

Unveiling the Power of Esketamine for Treatment-Resistant Depression

This research reveals the potential of esketamine as an adjunctive therapy for TRD, targeting specific symptoms of depression. The findings, like a hidden spring discovered in the desert of mental health treatment, offer a new avenue for addressing the challenges of this complex condition.

Finding Hope in the Desert of Depression: Esketamine for TRD

Imagine a weary traveler in the desert, seeking relief from relentless hardship. Esketamine, like a refreshing oasis, offers a potential solution for individuals struggling with TRD. This research provides valuable information about the effectiveness of esketamine in alleviating specific symptoms, highlighting its potential as a valuable tool in managing this challenging condition.

Dr. Camel's Conclusion

This study, like a guiding camel leading us through the complexities of mental health treatment, provides valuable insights into the potential of esketamine as an adjunctive therapy for TRD. The findings encourage further research into this novel treatment, offering hope for improved outcomes for individuals struggling with this challenging condition.

Date :
  1. Date Completed 2022-06-08
  2. Date Revised 2022-08-29
Further Info :

Pubmed ID

35441931

DOI: Digital Object Identifier

PMC9166828

Related Literature

Article Analysis
・Effects of esketamine nasal spray
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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