Starvation after infection restricts enterovirus D68 replication.

Author: GalitskaGanna, JacksonWilliam T, JasseyAlagie, MillerKatelyn, PaudelBimal, WagnerMichael A

Paper Details 
Original Abstract of the Article :
Enterovirus D68 (EV-D68) is a respiratory pathogen associated with acute flaccid myelitis, a childhood paralysis disease. No approved vaccine or antiviral treatment exists against EV-D68. Infection with this virus induces the formation of autophagosomes to enhance its replication but blocks the down...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809931/

データ提供:米国国立医学図書館(NLM)

Starvation's Unexpected Strength: A Novel Approach to Fighting Enterovirus D68

This [study] explores the fascinating world of [enterovirus D68 (EV-D68)] and its impact on human health. It's like a journey through a desert landscape, where we encounter a persistent enemy, EV-D68, that can cause [acute flaccid myelitis], a serious condition that can lead to paralysis. The researchers are searching for new ways to combat this viral foe, and they have discovered a surprising weapon: [starvation].

The study found that [starvation after infection (SAI)] effectively reduced EV-D68 replication in multiple cell lines. This suggests that SAI could be a potential antiviral strategy against EV-D68. Furthermore, the authors discovered that SAI induced [autophagic flux], a cellular process that helps to clear out damaged or unwanted components, during EV-D68 replication.

A Glimmer in the Desert: Exploiting Autophagy to Fight EV-D68

The study opens up a new avenue for antiviral research, suggesting that manipulating cellular processes like [autophagy] could be a powerful tool for fighting viral infections.

A Desert of Potential: A Novel Antiviral Strategy

This research offers a promising new approach to combating EV-D68, suggesting that [SAI] could potentially be a safe and effective treatment strategy. It's a glimmer of hope in the desert of viral infections, reminding us that there are still many untapped resources within the human body that we can harness to fight disease.

Dr. Camel's Conclusion

This study is like a desert oasis, revealing a surprising new strategy to combat EV-D68 by harnessing the power of starvation-induced autophagy. It's a testament to the ingenuity of science and a reminder that the desert of viral infections can hold unexpected treasures.

Date :
  1. Date Completed 2023-01-06
  2. Date Revised 2023-02-17
Further Info :

Pubmed ID

35446171

DOI: Digital Object Identifier

PMC9809931

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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