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Trifluridine induces HUVECs senescence by inhibiting mTOR-dependent autophagy.

Author: BaiShi-Rui, DaiQian-Long, HuaHui, JiaHui-Jie, ShiYi-Ling, VashisthManoj Kumar, WangXiao-Bo, XiaJing, ZhaoQi, ZhouMin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study evaluated the potential of trifluridine to induce senescence in human umbilical vein endothelial cells. The findings suggest that trifluridine can induce cellular senescence by inhibiting autophagy and activating the mTOR signaling pathway.
Paper Details　
Original Abstract of the Article :
Trifluridine, a key component of trifluridine/tipiracil, is a potential anti-cancer drug that can act effectively on refractory metastatic colorectal cancer. Chemotherapy is important for cancer treatment, but its adverse effects limit its use. Long-term side-effects caused by the drug used during c...See full text at original site
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引用元：
https://doi.org/10.1016/j.bbrc.2022.04.063

データ提供：米国国立医学図書館（NLM）

Trifluridine: A Double-Edged Sword in Cancer Treatment

Trifluridine, a promising anti-cancer drug, has shown effectiveness against refractory metastatic colorectal cancer. But like a double-edged sword, it can also induce cellular senescence, a process of aging that can limit its long-term use. This study explores the relationship between trifluridine and cellular senescence in human umbilical vein endothelial cells (HUVECs). The researchers investigated the effects of trifluridine on HUVECs and explored the underlying mechanisms involved in senescence induction.

Trifluridine: A Complex Journey Through the Desert of Senescence

The study found that trifluridine induced senescence in HUVECs, a process that involves the inhibition of autophagy, a cellular recycling system that helps maintain cell health. This discovery sheds light on the complex interplay between trifluridine, autophagy, and cellular senescence, suggesting that these processes may be intricately linked. This research is like navigating a complex desert, where every step can have a significant impact on the journey ahead.

Navigating the Side Effects of Cancer Treatment

The study's findings highlight the importance of understanding the potential side effects of cancer treatments, such as senescence induction. This knowledge is crucial for developing strategies to mitigate these effects and optimize treatment outcomes. It's like a wise desert nomad preparing for a long journey, understanding the challenges ahead and gathering the necessary resources to overcome them. This research is an important step in the ongoing quest for safer and more effective cancer therapies.

Dr.Camel's Conclusion

This research on trifluridine and cellular senescence reminds us that the desert of cancer treatment is full of complexities. Understanding the intricate relationships between drugs, cellular processes, and aging is essential for developing more effective and safer therapies. This study offers a valuable glimpse into this complex world, providing insights that could lead to new and innovative approaches to cancer treatment.

Date :
  1. Date Completed 2022-05-17
  2. Date Revised 2022-05-26
Further Info :

Pubmed ID

35462092

DOI: Digital Object Identifier

10.1016/j.bbrc.2022.04.063

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・Side Effects of trifluridine and tipiracil
SNS
PICO Info
in preparation
Languages

English

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