Immunomodulatory Effects of <i>&#945;</i>-Tocopherol on the H1N1 Influenza Vaccine: Improving the Potency and Efficacy of the Influenza Vaccine in Aged Mice.

Author: AbdoliAsghar, Abdollahpour-AlitappehMeghdad, EshraghiYasaman, KarimiPegah, MahdaviMehdi, TaghizadehMorteza, VahdaniYasaman

Paper Details 
Original Abstract of the Article :
Declined immune response is the main cause of decreased potency of the influenza vaccine in the elderly, regardless of virus mutations. Herein, we hypothesized that the addition of <i>&#945;</i>-tocopherol to the influenza vaccine formulation might increase vaccine potency and efficacy. Hemagglutini...See full text at original site
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引用元:
https://doi.org/10.1089/vim.2021.0154

データ提供:米国国立医学図書館(NLM)

Boosting Influenza Vaccine Efficacy with α-Tocopherol in Aged Mice

As we age, our immune systems naturally decline, making us more susceptible to infections. This study investigates the potential of α-tocopherol, a form of vitamin E, to enhance the efficacy of the influenza vaccine, particularly in older individuals. The researchers formulated an influenza vaccine containing α-tocopherol and tested its effects in both young and aged mice. The results revealed a significant improvement in both the immune response and the protection offered by the vaccine, especially in the aged mice. α-Tocopherol not only boosted the production of immune-related cytokines but also enhanced the levels of antibodies that fight off the influenza virus. Furthermore, the vaccine containing α-tocopherol provided greater protection against the influenza virus, evidenced by a reduced viral load in the lungs and increased survival rates. This promising study suggests that α-tocopherol could be a valuable addition to influenza vaccine formulations, particularly for older adults.

α-Tocopherol: A Potential Ally for a Robust Immune Response

These findings offer a compelling argument for further research into the potential of α-tocopherol as an adjuvant, a substance that enhances the effectiveness of vaccines. By bolstering the immune response in older individuals, α-tocopherol could play a vital role in preventing severe influenza infections and their associated complications. The potential of α-tocopherol extends beyond influenza; it could be a game-changer for improving vaccine efficacy across various age groups.

Implications for Everyday Life

As we navigate the ever-changing landscape of viruses and infections, protecting ourselves through vaccination remains paramount. This study suggests that α-tocopherol, commonly found in foods like almonds and spinach, could enhance the effectiveness of vaccines, especially for individuals with weakened immune systems. While it's always important to consult your doctor for personalized medical advice, incorporating α-tocopherol-rich foods into your diet may be a wise choice for overall health and well-being.

Dr. Camel's Conclusion

Imagine a camel navigating a desert, its hump providing a vital store of energy. Like a camel's hump, α-tocopherol can provide an extra boost for our immune system. This study unveils its potential to enhance the efficacy of the influenza vaccine, offering a beacon of hope for older adults seeking greater protection against this formidable virus. Perhaps, like the camel, we can learn to harness the power of nature to bolster our own resilience in the face of health challenges.

Date :
  1. Date Completed 2022-04-27
  2. Date Revised 2022-05-12
Further Info :

Pubmed ID

35467429

DOI: Digital Object Identifier

10.1089/vim.2021.0154

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SNS
PICO Info
in preparation
Languages

English

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