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Functional interaction between endothelin-1 and ZEB1/YAP signaling regulates cellular plasticity and metastasis in high-grade serous ovarian cancer.

Author: BagnatoAnna, Di CastroValeriana, RomanCelia, SestitoRosanna, TocciPiera

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Epithelial-to-mesenchymal transition (EMT) is a key process leading to metastatic progression in high-grade serous ovarian carcinoma (HG-SOC). Endothelin-1 (ET-1)/endothelin A receptor (ET<sub>A</sub>R) signaling promotes EMT driving tumor progression. This study aims to elucidate the complex nature of intertwined regulatory circuits activated by ET-1 to trigger the metastatic process.
Paper Details　
Original Abstract of the Article :
Label="BACKGROUND" NlmCategory="BACKGROUND">Epithelial-to-mesenchymal transition (EMT) encompasses a highly dynamic and complex key process which leads to metastatic progression. In high-grade serous ovarian carcinoma (HG-SOC), endothelin-1 (ET-1)/endothelin A receptor (ET<sub>A</sub>R) signaling pr...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047299/

データ提供：米国国立医学図書館（NLM）

Endothelin-1 and ZEB1/YAP Signaling: A Complex Dance of Metastasis in Ovarian Cancer

Ovarian cancer, a silent and often aggressive disease, can be likened to a treacherous desert, where tumors spread relentlessly. This study delves into the complex interplay between endothelin-1 (ET-1), ZEB1, and YAP signaling in the progression of high-grade serous ovarian cancer (HG-SOC). Researchers used [研究手法] to explore the role of ET-1/ETAR signaling in promoting epithelial-to-mesenchymal transition (EMT), a key process driving metastasis. The results unravel a complex network of regulatory circuits involved in tumor progression and metastasis.

A Complex Network of Metastasis Drivers

The study reveals that ET-1/ETAR signaling plays a pivotal role in driving EMT and promoting tumor progression. [研究結果] This highlights the importance of understanding these complex signaling pathways and developing targeted therapies to disrupt them and prevent metastasis.

Navigating the Desert of Ovarian Cancer

This study underscores the complexity of ovarian cancer and the need for a multi-pronged approach to treatment. By understanding the intricacies of signaling pathways involved in metastasis, we can develop more effective therapies and improve patient outcomes in the fight against this challenging disease.

Dr. Camel's Conclusion

The journey through the desert of ovarian cancer is fraught with challenges. This study provides crucial insights into the complex interplay between ET-1, ZEB1, and YAP signaling, paving the way for developing targeted therapies to combat this devastating disease.

Date :
  1. Date Completed 2022-04-29
  2. Date Revised 2022-07-16
Further Info :

Pubmed ID

35477522

DOI: Digital Object Identifier

PMC9047299

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Languages

English

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