Correction of thrombocytopenia caused by linezolid with scheduled sequential tedizolid use in patients with vertebral osteomyelitis by antibiotic resistant Gram-positive organisms.

Author: IchikiKaoru, IijimaKosuke, IkeuchiHiroki, IshiharaMika, IshikawaKaori, KimuraTakeshi, NakajimaKazuhiko, OtaniNaruhito, TakahashiYoshiko, TakesueYoshio, TakuboShingo, TsuchidaToshie, UchinoMotoi, UedaTakashi, YamadaKumiko

Paper Details 
Original Abstract of the Article :
Because of thrombocytopenia, linezolid treatment tends to be stopped before the completion of therapy for complicated infections that require prolonged antimicrobial administration. In contrast, tedizolid shows a favorable hematologic profile. The primary end-point of this study was to evaluate the ...See full text at original site
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引用元:
https://doi.org/10.1016/j.jiac.2022.04.003

データ提供:米国国立医学図書館(NLM)

Switching from linezolid to tedizolid to manage thrombocytopenia in vertebral osteomyelitis

The battle against infections, particularly those involving bone, can be a formidable journey, like crossing a vast desert under a scorching sun. This study, like a wise desert guide, explores the potential for switching from linezolid to tedizolid to manage thrombocytopenia, a condition that can complicate treatment. The study's focus on patients with vertebral osteomyelitis, a serious bone infection, highlights the need for alternative therapies when linezolid's side effects become problematic.

The study suggests a promising alternative for managing thrombocytopenia during prolonged antibiotic therapy

The study, like a camel caravan discovering a new oasis, presents a potential solution for a challenging dilemma. Switching from linezolid to tedizolid, known for its favorable hematologic profile, could provide a safe and effective way to continue treating infections while minimizing the risks of thrombocytopenia. This is like finding a new source of water in a parched desert, offering a lifeline for those facing difficult circumstances.

Implications for antibiotic therapy and patient management

The study's findings have important implications for antibiotic therapy, particularly for patients with complex infections requiring prolonged treatment. It suggests that switching to tedizolid could be a valuable option when linezolid-induced thrombocytopenia presents a significant challenge. This is like having a backup plan for a desert expedition, ensuring that the journey continues even if unforeseen obstacles arise.

Dr.Camel's Conclusion

This study, like a resilient desert plant thriving in harsh conditions, offers a potential solution for managing thrombocytopenia during prolonged antibiotic therapy. Switching from linezolid to tedizolid could provide a safer and more effective treatment path for patients with vertebral osteomyelitis, like finding a hidden oasis in a vast desert.

Date :
  1. Date Completed 2022-05-12
  2. Date Revised 2022-05-12
Further Info :

Pubmed ID

35477667

DOI: Digital Object Identifier

10.1016/j.jiac.2022.04.003

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