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Analysis of the nervous system and gastrointestinal adverse events associated with solifenacin in older adults using the US FDA adverse event reporting system.
Author: ChyouTe-Yuan, NichollsConnie, NishtalaPrasad S
Original Abstract of the Article :
BACKGROUND: Antimuscarinics are the backbone of the pharmacological management of overactive bladder. Still, concerns have been raised over the nervous system (NS) adverse drug events (AEs) due to their dissimilarities to muscarinic receptor-subtype affinities. OBJECTIVE: This study aimed to identi...See full text at original site
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引用元:
https://doi.org/10.3233/JRS-210054
データ提供:米国国立医学図書館(NLM)
Solifenacin: A Common Bladder Medication with Unexpected Side Effects
The field of geriatric medicine is constantly seeking safe and effective treatments for common health conditions in older adults. This study investigates the potential nervous system and gastrointestinal adverse drug events (ADEs) associated with solifenacin, a commonly prescribed medication for overactive bladder. The researchers analyzed reports submitted to the US FDA Adverse Event Reporting System (FAERS) and discovered a disproportionate reporting of "altered state of consciousness" in patients taking solifenacin. This finding suggests that solifenacin may be associated with an increased risk of this ADE in older adults.
Unveiling a Hidden Risk: Solifenacin and Altered State of Consciousness
This study raises concerns about the potential safety of solifenacin in older adults. The disproportionate reporting of "altered state of consciousness" suggests a possible link between solifenacin use and this ADE. The researchers emphasize the need for further investigation to confirm this association and explore the potential underlying mechanisms.
Navigating Medication Safety in Older Adults: A Call for Vigilance
This research highlights the importance of vigilant monitoring for ADEs in older adults, particularly those taking medications that can affect the nervous system. The findings emphasize the need for careful patient education, regular monitoring, and prompt reporting of any unusual symptoms. Healthcare providers should be aware of this potential ADE and consider alternative medications if necessary.
Dr.Camel's Conclusion
This study serves as a reminder of the importance of vigilant drug safety surveillance, particularly in older adults. The disproportionate reporting of "altered state of consciousness" associated with solifenacin raises concerns about the potential safety of this medication in this population. Further research is needed to confirm this finding and explore the potential implications for patient care.
Date :
- Date Completed 2023-01-17
- Date Revised 2023-02-28
Further Info :
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