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Beliefs About Medicines Predict Side-Effects of Placebo Modafinil.

Author: ChapmanSarah C E, HellerMonika K, HorneRob

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the nocebo effect, where patients taking a placebo report side effects. The study found that people who believe pharmaceuticals are harmful, are more sensitive to medication, have concerns about the drug, and experience negative emotions are more likely to experience nocebo effects. This suggests that beliefs about medication can influence the experience of side effects.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Patients receiving placebo in clinical trials often report side-effects (nocebo effects), but contributing factors are still poorly understood. PURPOSE: Using a sham trial of the cognition-enhancing "smart pill" Modafinil we tested whether medication beliefs and other psychological fact...See full text at original site
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引用元：
https://doi.org/10.1093/abm/kaab112

データ提供：米国国立医学図書館（NLM）

The Power of Beliefs: Understanding the Nocebo Effect in Placebo Trials

The world of clinical trials is a complex and fascinating desert, where the placebo effect often plays a significant role. This study explores the nocebo effect, the opposite of the placebo effect, where negative expectations lead to negative outcomes. The researchers investigated the role of beliefs about medications in influencing symptom reporting in a sham trial of Modafinil, a cognitive-enhancing drug. The study found that participants who held more negative beliefs about medications were more likely to report symptoms and attribute them to Modafinil side effects, highlighting the powerful influence of beliefs in shaping our experience of medication.

Navigating the Desert of Placebo Effects

The study's findings underscore the importance of addressing negative beliefs about medications in clinical trials and healthcare settings. By understanding the nocebo effect, researchers and clinicians can develop strategies to minimize its impact and ensure that patients receive the most effective and well-tolerated treatment. This research reminds us that the desert of placebo effects is a complex landscape, where our beliefs can influence our physical and psychological experiences.

The Power of Positive Expectations

This research highlights the importance of positive expectations in healthcare. By fostering positive beliefs about medications and promoting a supportive and empowering environment, healthcare providers can help minimize the nocebo effect and improve patient outcomes. This research reminds us that the desert of healthcare is not simply a physical landscape but also a psychological one, where our thoughts and beliefs can have a profound impact on our well-being.

Dr. Camel's Conclusion

This research delves into the fascinating and often overlooked realm of the nocebo effect, revealing the powerful influence of beliefs in shaping our experiences with medications. By understanding the nocebo effect, we can strive to create a more positive and supportive healthcare environment, where patients feel empowered and confident in their treatment.

Date :
  1. Date Completed 2022-10-05
  2. Date Revised 2022-11-18
Further Info :

Pubmed ID

35512392

DOI: Digital Object Identifier

10.1093/abm/kaab112

Related Literature

Article Analysis
・Side Effects of modafinil
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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