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[Therapy of malignant systemic diseases: hemoblastoses and malignant lymphomas].

Author: SchmidtC G

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
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Overview

A study of adult patients with acute myeloid leukemia (AML) found that maintenance chemotherapy after achieving complete remission significantly improved long-term remission rates. The study compared consolidation chemotherapy with and without monthly maintenance therapy, and found a 2.5-year continuous complete remission rate of 30% in the maintenance group compared to 17% in the non-maintenance group (p=0.003). This suggests that maintenance chemotherapy plays a crucial role in prolonging remission duration in AML.
Paper Details　
Original Abstract of the Article :
Recent progress in the treatment of acute leukemias in adults includes combination chemotherapy (TAD) and the use of high-dose antimetabolites (methotrexate plus citrovorum rescue or high-dose cytosine-arabinoside). The role of post-induction chemotherapy is still controversial especially with regar...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/3551972

データ提供：米国国立医学図書館（NLM）

Tackling Malignant Systemic Diseases: Advances in Hemoblastoses and Lymphomas

The battle against malignant systemic diseases like hemoblastoses and malignant lymphomas is a challenging journey. This study explores the latest advancements in the treatment of acute leukemias in adults, focusing on combination chemotherapy and high-dose antimetabolites. The researchers highlight the role of post-induction chemotherapy, a crucial step in the treatment process, and delve into the debate surrounding maintenance chemotherapy. Their findings provide compelling evidence that post-induction myelosuppressive chemotherapy plays a vital role in achieving long-term remission in acute myeloid leukemia (AML). The study also suggests that consolidation chemotherapy combined with monthly maintenance chemotherapy may be superior to consolidation alone in prolonging remission duration.

Post-Induction Chemotherapy: A Key Player in Leukemia Treatment

The results of this study emphasize the importance of post-induction chemotherapy in the treatment of AML. The predicted rate of continuous complete remission at 2 1/2 years was significantly higher for patients who received maintenance chemotherapy (30%) compared to those who did not (17%). This difference underscores the crucial role of post-induction therapy in improving long-term outcomes for AML patients. It's like giving a thirsty camel a refreshing drink of water after a long trek through the desert.

Improving Treatment Outcomes: The Impact of Maintenance Chemotherapy

The study's findings suggest that maintenance chemotherapy, following consolidation therapy, may further enhance remission duration in AML. This is particularly significant as it may lead to longer periods of improved health and quality of life for patients. As a researcher, I see this as a vital step towards improving the lives of those affected by these challenging diseases. Imagine a camel, having survived the harsh desert, being provided with regular nourishment to ensure its continued strength and resilience. This is the essence of maintenance chemotherapy in the context of leukemia treatment.

Dr.Camel's Conclusion

The fight against malignant systemic diseases is an ongoing journey, much like a camel traversing a vast and unforgiving desert. This study illuminates the importance of post-induction chemotherapy and the potential benefits of maintenance therapy in improving outcomes for patients with acute leukemias. It's a testament to the tireless efforts of researchers who strive to make a difference in the lives of those battling these challenging conditions.

Date :
  1. Date Completed 1987-05-12
  2. Date Revised 2007-11-15
Further Info :

Pubmed ID

3551972

DOI: Digital Object Identifier

3551972

SNS
PICO Info
in preparation
Languages

German

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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