Interim results from a postmarketing surveillance study of patients with FLT3-mutated relapsed/refractory AML treated with the FLT3 inhibitor gilteritinib in Japan.

Author: LeeTakumi, MitomiTakeshi, SugamoriHaruko, YamagishiChika

Paper Details 
Original Abstract of the Article :
OBJECTIVE: Gilteritinib received approval for the treatment of FLT3-mutated relapsed or refractory acute myeloid leukemia in Japan in 2018. In accordance with regulatory requirements, we conducted a multicenter, observational surveillance of gilteritinib use in Japan. METHODS: Patients were followe...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264337/

データ提供:米国国立医学図書館(NLM)

Navigating the Desert of Relapsed/Refractory AML: Gilteritinib as a Treatment Option

Acute myeloid leukemia (AML), a formidable adversary in the world of hematologic malignancies, can often return even after treatment. This study explores the use of gilteritinib, a FLT3 inhibitor, in patients with FLT3-mutated relapsed/refractory AML, a challenging subset of the disease.

The authors, like seasoned desert explorers, navigate the complex landscape of AML treatment, evaluating the efficacy and safety of gilteritinib in a real-world setting. Their findings provide valuable insights into the impact of this targeted therapy in this challenging patient population.

Gilteritinib: A Potential Weapon Against Relapsed/Refractory AML

This study, like a well-stocked oasis in the desert of AML treatment, offers a glimmer of hope for patients with relapsed/refractory AML. Gilteritinib, a targeted therapy specifically designed to inhibit the FLT3 mutation, demonstrates promising efficacy in this challenging subset of the disease. However, the study also highlights the importance of careful monitoring and management of potential adverse events.

Precision Medicine: A New Era in Cancer Treatment

This research underscores the growing importance of precision medicine in cancer treatment. By targeting specific genetic mutations, like a skilled archer aiming for a specific target in the desert, we can develop more effective and personalized therapies. Gilteritinib, a testament to this approach, offers a potential breakthrough in the fight against AML.

Dr. Camel's Conclusion

The desert of AML treatment is vast and complex, but gilteritinib offers a promising oasis of hope for patients with relapsed/refractory AML. This study demonstrates the potential of precision medicine to provide targeted and effective therapies, like a desert oasis providing sustenance and rejuvenation. The journey to conquer AML is ongoing, and this research is a testament to the power of ongoing innovation and scientific discovery.

Date :
  1. Date Completed 2022-07-11
  2. Date Revised 2022-12-06
Further Info :

Pubmed ID

35523692

DOI: Digital Object Identifier

PMC9264337

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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