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Unraveling enhanced brain delivery of paliperidone-loaded lipid nanoconstructs: pharmacokinetic, behavioral, biochemical, and histological aspects.

Author: AliJaved, AnsariMohammad Javed, BabootaSanjula, IqubalAshif, JavedAmaan, KhanTahira, NabiBushra, RehmanSaleha

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Paliperidone (PPD)-loaded lipid nanoconstructs (PPD-LNC) demonstrated improved antipsychotic activity and reduced extrapyramidal symptoms compared to PPD suspension in a preclinical study. The LNC formulation showed a 3.46-fold improvement in brain bioavailability, reduced cataleptic behavior, and improved spatial memory in rats. The formulation also exhibited anti-inflammatory effects and attenuated neuroinflammatory markers, suggesting potential for improved management of schizophrenia with fewer side effects.
Paper Details　
Original Abstract of the Article :
Antipsychotics are accompanied by extrapyramidal side effects that deter treatment adherence and patient compliance. Paliperidone (PPD), an atypical (second-generation) antipsychotic recommended for managing schizophrenia presents biopharmaceutical challenges and pharmacological constraints which di...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103378/

データ提供：米国国立医学図書館（NLM）

Enhanced Brain Delivery of Paliperidone for Schizophrenia Treatment

This study examines the potential of a novel formulation of paliperidone (PPD) for treating schizophrenia, focusing on improving brain delivery and reducing side effects. Imagine a desert traveler who needs to find a way to cross a challenging terrain safely and effectively. This study explores a new path for delivering medication to the brain to address the complexities of schizophrenia.

Paliperidone-Loaded Lipid Nanoconstructs (PPD-LNC)

The study investigates the use of paliperidone-loaded lipid nanoconstructs (PPD-LNC) as a novel delivery system for PPD. PPD-LNCs demonstrated significantly improved brain delivery compared to traditional PPD formulations, leading to enhanced antipsychotic activity. Additionally, PPD-LNCs showed reduced extrapyramidal side effects and improved neuroinflammatory markers. This is like finding a new type of camel that can navigate treacherous terrain with greater efficiency and less risk of getting lost.

Improving Schizophrenia Treatment

This research offers a promising new approach for treating schizophrenia, highlighting the potential of nano-formulation technology to improve brain delivery and reduce side effects. This research represents a significant step toward improving the lives of individuals living with schizophrenia, providing them with greater hope for a better future.

Dr.Camel's Conclusion

This study explores the exciting potential of lipid nanoconstructs for enhancing the delivery of paliperidone to the brain, paving the way for more effective and well-tolerated treatments for schizophrenia. It underscores the importance of continued innovation in drug delivery technologies to address complex medical challenges and improve the well-being of individuals around the world.
Date :
  1. Date Completed 2022-05-10
  2. Date Revised 2022-08-01
Further Info :

Pubmed ID

35532148

DOI: Digital Object Identifier

PMC9103378

Related Literature

Article Analysis
・Side Effects of paliperidone
SNS
PICO Info
in preparation
Languages

English

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