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Superiority of microemulsion-based hydrogel for non-steroidal anti-inflammatory drug transdermal delivery: a comparative safety and anti-nociceptive efficacy study.

Author: AblaKawthar K, DomiatiSouraya, ElmaradnyHoda, MehannaMohammed M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigates the development of diclofenac-loaded hydrogels for topical delivery of non-steroidal anti-inflammatory drugs (NSAIDs). The authors compared microemulsion-based hydrogel (MBH), proliposomal, and cubosomal gels in terms of physicochemical properties, drug release, skin permeation, and anti-nociceptive efficacy. MBH demonstrated superior skin permeation and anti-nociceptive effect with minimal irritation, suggesting its potential as a safe and effective topical delivery system for NSAIDs.
Paper Details　
Original Abstract of the Article :
Non-steroidal anti-inflammatory drugs (NSAIDs) represent the foundation of pain management caused by inflammatory disorders. Nevertheless, their oral administration induces several side effects exemplified by gastric ulceration, thus, delivering NSAIDs via skin has become an attractive alternative. ...See full text at original site
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引用元：
https://doi.org/10.1016/j.ijpharm.2022.121830

データ提供：米国国立医学図書館（NLM）

Microemulsion-Based Hydrogel for Transdermal Delivery of NSAIDs

Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to manage pain, but oral administration can lead to side effects. This research explored the potential of [transdermal delivery] using a [microemulsion-based hydrogel (MBH)] to deliver diclofenac, an NSAID. They compared MBH to proliposomal and cubosomal gels in terms of safety, efficacy, and skin permeation.

MBH Offers Superior Transdermal Delivery of Diclofenac

The study found that [MBH demonstrated superior skin permeation] compared to other formulations. It also showed a significant anti-nociceptive effect in a tail-flick test and was well tolerated, with no observed irritation or systemic toxicity. This suggests that MBH could be a promising vehicle for delivering NSAIDs through the skin. It’s like discovering a new type of camel caravan, one that can navigate the desert with greater efficiency and comfort.

Navigating Pain Management: Finding the Right Path

Pain management is a complex area, and finding the right treatment can be like navigating a vast and challenging desert. This research offers a promising alternative to oral NSAIDs, with the potential for improved delivery and fewer side effects. It’s important to work with a healthcare professional to determine the best approach for managing pain.

Dr. Camel's Conclusion

This study explores the potential of MBH as a vehicle for transdermal delivery of NSAIDs. The findings suggest that MBH offers a promising alternative to oral NSAIDs, potentially leading to improved efficacy and fewer side effects.

Date :
  1. Date Completed 2022-06-21
  2. Date Revised 2022-06-21
Further Info :

Pubmed ID

35589005

DOI: Digital Object Identifier

10.1016/j.ijpharm.2022.121830

Related Literature

Article Analysis
・Side Effects of diclofenac
SNS
PICO Info
in preparation
Languages

English

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