Paper Details 
Original Abstract of the Article :
Olanzapine is a second-generation antipsychotic with established efficacy in several psychiatric disease states, but its use is limited because of weight gain and metabolic side effects. Samidorphan is a novel opioid antagonist that binds to mu-opioid, kappa-opioid, and delta-opioid receptors and is...See full text at original site
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引用元:
https://doi.org/10.1007/s40263-022-00923-3

データ提供:米国国立医学図書館(NLM)

Olanzapine/Samidorphan: A New Oasis in the Desert of Antipsychotic Side Effects

The treatment of mental health conditions is a vast and complex desert, often riddled with side effects that can affect a patient's quality of life. This study explores the potential of a new combination treatment, olanzapine/samidorphan, for schizophrenia and bipolar I disorder, focusing on its ability to mitigate the weight gain commonly associated with olanzapine monotherapy. The researchers investigated the efficacy and tolerability of this combination, finding that it may offer a more tolerable option for patients by reducing weight gain and other metabolic side effects.

A New Oasis in the Desert of Weight Gain: Olanzapine/Samidorphan

The combination of olanzapine/samidorphan showed a significant reduction in weight gain compared to olanzapine monotherapy. This finding is particularly important, as weight gain is a significant concern for patients taking olanzapine and can lead to medication nonadherence.

Navigating the Desert of Mental Health Treatment: Choosing a Tolerable Option

This research offers a valuable insight into the ongoing search for better, more tolerable treatment options for mental health conditions. By reducing weight gain, olanzapine/samidorphan may help patients navigate the challenging terrain of treatment with fewer side effects and greater adherence to their medication regimen.

Dr. Camel's Conclusion

This research offers a promising new pathway in the desert of mental health treatment, suggesting that olanzapine/samidorphan may provide a more tolerable option for patients with schizophrenia and bipolar I disorder, particularly those concerned about weight gain. Further research is needed to explore the long-term effects of this combination treatment, but it offers a potential oasis of hope in the challenging landscape of mental health care.

Date :
  1. Date Completed 2022-06-08
  2. Date Revised 2022-08-29
Further Info :

Pubmed ID

35644903

DOI: Digital Object Identifier

10.1007/s40263-022-00923-3

Related Literature

SNS
PICO Info
in preparation
Languages

English

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