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Identifying and treating resistant hypertension in PRECISION: A randomized long-term clinical trial with aprocitentan.

Author: , BelletMarc, DanaietashParisa, DresserGeorge, KantolaIlkka, LawrenceMary Katherine, NarkiewiczKrzysztof, SchlaichMarkus, VerweijPierre, WangJi-Guang

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study, called PRECISION, evaluates the effect of the dual endothelin receptor antagonist aprocitentan on blood pressure (BP) in patients with resistant hypertension (RHT). The study found that a high proportion of patients referred for RHT actually had pseudoresistant hypertension, highlighting the need for careful screening and evaluation.
Paper Details　
Original Abstract of the Article :
The design and baseline data of the PRECISION study, which evaluates the effect of the dual endothelin receptor antagonist aprocitentan on blood pressure (BP) in patients with resistant hypertension (RHT) are presented. The study is a blinded, randomized, parallel-group Phase 3 study and its three-p...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278594/

データ提供：米国国立医学図書館（NLM）

Aprocitentan: A Promising Treatment for Resistant Hypertension

This research investigates the efficacy of aprocitentan, a dual endothelin receptor antagonist, in treating resistant hypertension (RHT), a challenging condition characterized by uncontrolled blood pressure despite multiple medications. It’s like seeking a new remedy for a persistent desert sandstorm. The researchers designed a large, randomized clinical trial to evaluate the effects of aprocitentan on blood pressure. The study's unique three-part design allows for assessment of both short-term and sustained long-term effects. The results are expected to provide valuable insights into the potential of aprocitentan as a treatment for RHT.

Aprocitentan: Potential for Long-Term Blood Pressure Control

This research offers a promising new approach for treating RHT, a condition that can significantly impact cardiovascular health. The study, with its comprehensive design, aims to demonstrate the long-term effectiveness of aprocitentan in lowering and controlling blood pressure. This is like finding a way to permanently redirect a sandstorm, preventing it from causing further damage.

Health Impact and Application in Daily Life

This research offers hope for individuals struggling with RHT, a condition that can have serious health consequences. The study highlights the potential of aprocitentan as a long-term solution for managing blood pressure. However, it's essential to consult with a healthcare provider to determine the best treatment option for individual patients.

Dr.Camel's Conclusion

This research is like a desert oasis, offering a potential respite from the relentless sandstorm of resistant hypertension. Aprocitentan emerges as a beacon of hope, potentially providing a more sustainable solution for managing blood pressure. It's a reminder that even in the most challenging deserts, perseverance and innovation can lead to a better tomorrow.

Date :
  1. Date Completed 2022-07-15
  2. Date Revised 2022-09-23
Further Info :

Pubmed ID

35686330

DOI: Digital Object Identifier

PMC9278594

Related Literature

Article Analysis
・Effects of aprocitentan
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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