Mebendazole, an anti-helminth drug, suppresses inflammation, oxidative stress and injury in a mouse model of ulcerative colitis.

Author: AhadiMitra, AsgharzadehFereshteh, Askarnia-FaalMohammad Mostafa, AvanAmir, EskandariMoein, FernsGordon, GharibMasoumeh, HassanianSeyed Mahdi, KhazaeiMajid, NaghibzadehNiloufar, NaimiHamideh, RyzhikovMikhail, SoleimaniAtena, VossoughiniaHassan

Paper Details 
Original Abstract of the Article :
Mebendazole (MBZ) is an efficacious anthelmintic with known anti-inflammatory and fibrinolytic properties. In this study, we aimed to explore the protective effects of this FDA-approved drug against DSS-induced colitis in a murine model either alone or in combination with Sulfasalazine (SSZ), a stan...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205960/

データ提供:米国国立医学図書館(NLM)

Mebendazole: A Potential New Weapon in the Fight Against Ulcerative Colitis

Ulcerative colitis (UC), a chronic inflammatory bowel disease, can significantly impact a person's quality of life. This study explores the potential of mebendazole, a widely used anti-helminth drug, as a new treatment for UC. It's like discovering a hidden oasis in the desert, offering a new path towards managing this challenging disease.

A Surprising Ally: Mebendazole's Protective Effects

The study found that mebendazole significantly improved disease activity in a mouse model of UC. The drug reduced inflammation, oxidative stress, and tissue damage, demonstrating a protective effect against UC. It's like finding a hidden spring in the desert, offering a source of relief from the harsh conditions. The study also found that mebendazole effectively reduced fibrosis, a complication that can lead to long-term damage.

A New Hope for Treatment

This research presents a compelling case for repurposing mebendazole as a treatment for UC. The study's findings, like finding a new trail in a vast desert, offer a promising avenue for developing new therapies that are both effective and safe. Further research is needed to confirm these results in human patients, but the study offers a ray of hope for those struggling with this debilitating disease.

Dr. Camel's Conclusion

This study offers a promising new direction in the treatment of ulcerative colitis. The potential of mebendazole, a well-established and safe drug, is a significant finding, offering a potential new weapon in the fight against this chronic disease. It's a reminder that even in the face of challenging health conditions, there is always hope for new treatments and therapies. The desert of UC research is vast, but with continued exploration and innovation, we can find new paths towards effective management and ultimately, a cure.

Date :
  1. Date Completed 2022-06-21
  2. Date Revised 2022-08-19
Further Info :

Pubmed ID

35715495

DOI: Digital Object Identifier

PMC9205960

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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