Unveiling the mechanism of action of nature-inspired anti-cancer compounds using a multi-omics approach.

Author: Al-HroubHamza M, Al-TelTaleb H, AliAmjad, GiddeyAlexander D, HamadMawieh, OkendoJavan, SemreenMohammad H, SharafBasma M, SoaresNelson C, SrinivasuluVunnam

Paper Details 
Original Abstract of the Article :
The 2020 global cancer registry has ranked breast cancer (BCa) as the most commonly diagnosed type of cancer and the most common cause of cancer-related deaths in women worldwide. Increasing resistance and significant side effects continue to limit the efficacy of anti-BCa drugs, hence the need to i...See full text at original site
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引用元:
https://doi.org/10.1016/j.jprot.2022.104660

データ提供:米国国立医学図書館(NLM)

Unlocking Nature's Secrets: Multi-Omics Approach to Cancer

The fight against breast cancer, like a relentless desert battle, requires a multi-pronged approach. This study, a journey into the depths of cellular biology, employs a multi-omics strategy to unravel the mechanisms of action of two nature-inspired anti-cancer compounds, SIMR3066 and SIMR3058. The researchers, like skilled desert cartographers, map the complex landscape of cellular processes, seeking to understand how these compounds impact breast cancer cells.

A Multi-Omics Approach: Mapping the Cellular Terrain

The researchers utilized a multi-omics approach, combining proteomics and metabolomics, to provide a comprehensive view of how these compounds affect breast cancer cells. This is akin to using multiple maps to navigate a vast and intricate desert, gaining a deeper understanding of the terrain. The study's findings, like a carefully constructed map of the cellular landscape, reveal significant changes in protein expression and metabolic pathways in response to these compounds.

Nature's Arsenal: Promise for New Treatments

The authors, in their exploration of nature's arsenal, demonstrate the potential of these nature-inspired compounds to disrupt crucial pathways involved in breast cancer cell growth and survival. This is like discovering a hidden oasis in the desert, offering a source of potential relief and hope for a more effective treatment. Their findings highlight the importance of exploring natural compounds as a source of novel anti-cancer therapies.

Dr. Camel's Conclusion

This study, like a caravan navigating a vast desert, explores the potential of nature-inspired compounds to combat breast cancer. The researchers' multi-omics approach, much like using multiple maps to navigate a complex terrain, provides valuable insights into the mechanisms of action of these compounds, revealing their potential to disrupt key pathways involved in breast cancer cell growth and survival. This research serves as a reminder of the power of nature's pharmacy and its potential to offer new solutions to challenging health conditions.

Date :
  1. Date Completed 2022-07-07
  2. Date Revised 2022-09-18
Further Info :

Pubmed ID

35728772

DOI: Digital Object Identifier

10.1016/j.jprot.2022.104660

Related Literature

SNS
PICO Info
in preparation
Languages

English

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