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Clinical Study of Aspirin and Zileuton on Biomarkers of Tobacco-Related Carcinogenesis in Current Smokers.

Author: AlekseyevYuriy O, BaumanJulie E, BeaneJennifer, ChowH-H Sherry, DavisLisa E, GarlandLinda L, Guillen-RodriguezJosé, HsuChiu-Hsieh, HustedChristopher R, LeClercAshley, LiuGang, LiuHanqiao, SpiraAvrum E, SzaboEva, WojtowiczMalgorzata

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Aspirin and other NSAIDs have chemopreventive effects on lung cancer risk. This study investigated the effects of low-dose aspirin plus zileuton, a 5-lipoxygenase inhibitor, on nasal epithelium gene signatures in smokers. While the combination had minimal effects on smoking-related gene signatures, it favorably modulated a bronchial gene expression signature of squamous dysplasia. Further investigation is needed to understand the long-term effects of this combination.
Paper Details　
Original Abstract of the Article :
The chemopreventive effect of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) on lung cancer risk is supported by epidemiologic and preclinical studies. Zileuton, a 5-lipoxygenase inhibitor, has additive activity with NSAIDs against tobacco carcinogenesis in preclinical models. We h...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221101/

データ提供：米国国立医学図書館（NLM）

The Chemopreventive Potential of Aspirin and Zileuton: A New Hope for Smokers?

The desert of smoking-related carcinogenesis is a harsh and unforgiving landscape, filled with the dangers of lung cancer. This study, like a search for a hidden oasis in this desolate terrain, explores the chemopreventive effects of aspirin and zileuton on biomarkers of tobacco-related carcinogenesis in current smokers. The study aimed to understand whether these medications could help mitigate the risk of lung cancer in smokers.

A Promising Combination for Smokers

The study found that while aspirin and zileuton had minimal effects on the modulation of nasal or bronchial gene expression signatures of smoking, lung cancer, and COPD, they favorably modulated a bronchial gene expression signature of squamous dysplasia. These findings suggest that this combination might have a positive impact on the prevention of certain types of lung cancer, offering a glimmer of hope for smokers seeking to reduce their risk.

Navigating the Desert of Smoking-Related Carcinogenesis

This study provides a valuable roadmap for exploring the potential of aspirin and zileuton as chemopreventive agents for smokers. Further research is needed to confirm these findings and fully understand the long-term effects of this combination, but these findings offer a promising direction for developing strategies that can help smokers navigate the treacherous landscape of smoking-related carcinogenesis.

Dr.Camel's Conclusion

This research offers a potential oasis in the harsh desert of smoking-related carcinogenesis, suggesting that aspirin and zileuton may have chemopreventive effects for smokers. While more research is needed to confirm these findings, this study provides a promising direction for developing strategies that can help smokers mitigate their risk of lung cancer. The desert of smoking-related carcinogenesis is vast and complex, but this study offers a beacon of hope, highlighting the potential for interventions that can make the journey through this challenging landscape a bit safer.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-07-16
Further Info :

Pubmed ID

35740559

DOI: Digital Object Identifier

PMC9221101

Related Literature

Article Analysis
・Effects of zileuton
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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