Paper Details

  1. Home
  2. Paper Details

Eosinophilic esophagitis: Immune mechanisms and therapeutic targets.

Author: ChangJoy W, ChehadeMirna, HoganSimon P, IdelmanGila, KhokharDilawar, MarellaSahiti

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus. It causes difficulty swallowing and food getting stuck in the esophagus. This article discusses the immune system and cells that are involved in EoE and how new treatments are being developed.
Paper Details　
Original Abstract of the Article :
Eosinophilic esophagitis (EoE) is an emerging chronic inflammatory disease of the oesophagus and is clinically characterized by upper gastrointestinal (GI) symptoms including dysphagia and esophageal food impaction. Histopathologic manifestations, which include intraepithelial eosinophilic inflammat...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/35778876

データ提供：米国国立医学図書館（NLM）

Eosinophilic Esophagitis: Unveiling the Immune Mechanisms and Therapeutic Targets

Eosinophilic esophagitis (EoE) is a chronic inflammatory condition of the esophagus that can cause discomfort and difficulty swallowing. This review focuses on the immune mechanisms underlying EoE, highlighting the role of the IL-13/CCL26/eosinophil axis in driving the disease. The author discusses the contribution of this inflammatory pathway to the histological manifestations of EoE, including eosinophilic inflammation and epithelial changes. The review also explores emerging therapeutic targets for EoE, focusing on treatments that aim to modulate the immune response and restore the esophageal epithelium.

New Horizons in EoE Treatment: Targeting the Immune System

This review underscores the growing understanding of the immune mechanisms driving EoE. By targeting the IL-13/CCL26/eosinophil axis, researchers are developing novel therapies that may offer more effective and targeted treatment options for patients with EoE.

Managing EoE: A Journey of Understanding

Living with EoE can be challenging, but understanding the underlying immune mechanisms is crucial for effective management. This review highlights the importance of working closely with a healthcare provider to develop a personalized treatment plan that addresses the specific needs of each individual.

Dr.Camel's Conclusion

This review is like a camel caravan navigating a challenging desert landscape, providing insights into the complex immune mechanisms driving EoE. By understanding the disease's origins, researchers are developing new and innovative therapies that offer hope for improved outcomes for patients.

Date :
  1. Date Completed 2022-10-06
  2. Date Revised 2023-08-10
Further Info :

Pubmed ID

35778876

DOI: Digital Object Identifier

NIHMS1820977

Related Literature

Article Analysis
・Effective treatment of eosinophilic disorders
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.